Makoto Koizumi

Allosteric selection of ribozymes that respond to the second messengers cGMP and cAMP.

Ronald R. Breaker, Makoto Koizumi, Garrett A. Soukup et al. · Nature Structural Biology · 1999 · 184 citations

Life Sciences, Biochemistry, Molecular Biology +12

2′-O,4′-C-ethylene-bridged nucleic acids (ENA): highly nuclease-resistant and thermodynamically stable oligonucleotides for antisense drug

Koji Morita, Chikako Hasegawa, Masakatsu Kaneko et al. · Bioorganic & Medicinal Chemistry Letters · 2002 · 184 citations

Pharmacy, Biochemistry, Molecular Biology +15

Effects of phosphorothioate and 2-amino groups in hammerhead ribozymes on cleavage rates and magnesium binding

Makoto Koizumi, Eiko Ohtsuka · Biochemistry · 1991 · 181 citations

Life Sciences, Biochemistry, Molecular Biology +13

Synthesis and properties of 2′-O,4′-C-Ethylene-Bridged nucleic acids (ENA) as effective antisense oligonucleotides

Koji Morita, Miho Takagi, Chikako Hasegawa et al. · Bioorganic & Medicinal Chemistry · 2003 · 131 citations

Pharmacy, Chemistry, Molecular Biology +14

Design of RNA enzymes distinguishing a single base mutation in RNA

Makoto Koizumi, Yoji Hayase, Shigenori Iwai et al. · Nucleic Acids Research · 1989 · 126 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13