Concepedia

2′-O,4′-C-ethylene-bridged nucleic acids (ENA): highly nuclease-resistant and thermodynamically stable oligonucleotides for antisense drug

Koji Morita, Chikako Hasegawa, Masakatsu Kaneko, Shinya Tsutsumi, Junko Sone, T. Ishikawa, Takeshi Imanishi, Makoto Koizumi

Bioorganic & Medicinal Chemistry Letters · 2002 · 184 citations · 11 references

DOI

Concepts

References

11

LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition

Alexei A. Koshkin, Sanjay K. Singh, Poul Nielsen et al. · Tetrahedron · 1998 · 1K citations

, , +16

Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2′-O,4′-C-methyleneribonucleosides

Satoshi Obika, Daishu Nanbu, Yoshiyuki Hari et al. · Tetrahedron Letters · 1998 · 693 citations

, , +16

The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes

Sandra Freier · Nucleic Acids Research · 1997 · 684 citations · Full text

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Potent and nontoxic antisense oligonucleotides containing locked nucleic acids

Claes Wahlestedt, Peter Salmi, Liam Good et al. · Proceedings of the National Academy of Sciences · 2000 · 620 citations

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Synthesis of 2′-O,4′-C-methyleneuridine and -cytidine. Novel bicyclic nucleosides having a fixed C3, -endo sugar puckering

Satoshi Obika, Daishu Nanbu, Yoshiyuki Hari et al. · Tetrahedron Letters · 1997 · 601 citations

, , +13