Alexei A. Koshkin

LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition

Alexei A. Koshkin, Sanjay K. Singh, Poul Nielsen et al. · Tetrahedron · 1998 · 1K citations

Nucleic Acid Chemistry, Dna, Biochemistry +9

LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition

Sanjay K. Singh, Alexei A. Koshkin, Jesper Wengel et al. · Chemical Communications · 1998 · 762 citations

Thermal Stabilities, Nucleic Acid Chemistry, Natural Sciences +12

Potent and nontoxic antisense oligonucleotides containing locked nucleic acids

Claes Wahlestedt, Peter Salmi, Liam Good et al. · Proceedings of the National Academy of Sciences · 2000 · 615 citations · Full text

Molecular Pharmacology, Rnase H, Nucleic Acid Chemistry +14

LNA (Locked Nucleic Acid):  An RNA Mimic Forming Exceedingly Stable LNA:LNA Duplexes

Alexei A. Koshkin, Poul Nielsen, Michael Meldgaard et al. · Journal of the American Chemical Society · 1998 · 338 citations

Genetics, Altmetric Attention Score, Molecular Biology +22

The first analogues of LNA (Locked Nucleic Acids): Phosphorothioate-LNA and 2′-thio-LNA

Ravindra Kumar, Sanjay K. Singh, Alexei A. Koshkin et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 216 citations

Nucleic Acid Chemistry, Bioorganic Chemistry, First Analogues +8