Takeshi Imanishi

Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2′-O,4′-C-methyleneribonucleosides

Satoshi Obika, Daishu Nanbu, Yoshiyuki Hari et al. · Tetrahedron Letters · 1998 · 693 citations

Life Sciences, Chemistry, Molecular Biology +16

Synthesis of 2′-O,4′-C-methyleneuridine and -cytidine. Novel bicyclic nucleosides having a fixed C3, -endo sugar puckering

Satoshi Obika, Daishu Nanbu, Yoshiyuki Hari et al. · Tetrahedron Letters · 1997 · 601 citations

Natural Sciences, Biochemistry, Chemistry +13

2′-O,4′-C-ethylene-bridged nucleic acids (ENA): highly nuclease-resistant and thermodynamically stable oligonucleotides for antisense drug

Koji Morita, Chikako Hasegawa, Masakatsu Kaneko et al. · Bioorganic & Medicinal Chemistry Letters · 2002 · 184 citations

Pharmacy, Biochemistry, Molecular Biology +15

Design, Synthesis, and Properties of 2‘,4‘-BNA^NC:  A Bridged Nucleic Acid Analogue

S. M. Abdur Rahman, Satoshi Obika, Haruhisa Yoshikawa et al. · Journal of the American Chemical Society · 2008 · 160 citations

Pharmacy, Chemistry, Molecular Biology +17

2′-O,4′-C-methylene bridged nucleic acid (2′,4′-BNA)

Satoshi Obika, Takeshi Uneda, Tomomi Sugimoto et al. · Bioorganic & Medicinal Chemistry · 2001 · 148 citations

Life Sciences, Biochemistry, Molecular Biology +7