Koji Morita

2′-O,4′-C-ethylene-bridged nucleic acids (ENA): highly nuclease-resistant and thermodynamically stable oligonucleotides for antisense drug

Koji Morita, Chikako Hasegawa, Masakatsu Kaneko et al. · Bioorganic & Medicinal Chemistry Letters · 2002 · 183 citations

2′-O,4′-c-ethylene-bridged Nucleic Acids, Nucleic Acid Chemistry, Antisense Drug +8

A Novel HER3-Targeting Antibody–Drug Conjugate, U3-1402, Exhibits Potent Therapeutic Efficacy through the Delivery of Cytotoxic Payload by Efficient Internalization

Yuuri Hashimoto, Kumiko Koyama, Yasuki Kamai et al. · Clinical Cancer Research · 2019 · 164 citations

Novel antibody drug conjugates containing exatecan derivative-based cytotoxic payloads

Takashi Nakada, Takeshi Masuda, Hiroyuki Naito et al. · Bioorganic & Medicinal Chemistry Letters · 2016 · 152 citations

Medicine, Radiation Oncology, Antibody Engineering +1

Synthesis and properties of 2′-O,4′-C-Ethylene-Bridged nucleic acids (ENA) as effective antisense oligonucleotides

Koji Morita, Miho Takagi, Chikako Hasegawa et al. · Bioorganic & Medicinal Chemistry · 2003 · 129 citations

2′-O,4′-c-ethylene-bridged Nucleic Acids, Nucleic Acid Chemistry, Natural Sciences +5

Effects on RNA Interference in Gene Expression (RNAi) in Cultured Mammalian Cells of Mismatches and the Introduction of Chemical Modifications at the 3′-Ends of siRNAs

Makiko Hamada, Toshiaki Ohtsuka, Reimi Kawaida et al. · Antisense and Nucleic Acid Drug Development · 2002 · 110 citations

Genetics, Chemical Modification, Molecular Biology +20