Koji Morita

2′-O,4′-C-ethylene-bridged nucleic acids (ENA): highly nuclease-resistant and thermodynamically stable oligonucleotides for antisense drug

Koji Morita, Chikako Hasegawa, Masakatsu Kaneko et al. · Bioorganic & Medicinal Chemistry Letters · 2002 · 184 citations

Pharmacy, Biochemistry, Molecular Biology +15

A Novel HER3-Targeting Antibody–Drug Conjugate, U3-1402, Exhibits Potent Therapeutic Efficacy through the Delivery of Cytotoxic Payload by Efficient Internalization

Yuuri Hashimoto, Kumiko Koyama, Yasuki Kamai et al. · Clinical Cancer Research · 2019 · 174 citations

Medicine, Oncology, Pharmacology +15

Novel antibody drug conjugates containing exatecan derivative-based cytotoxic payloads

Takashi Nakada, Takeshi Masuda, Hiroyuki Naito et al. · Bioorganic & Medicinal Chemistry Letters · 2016 · 169 citations

Pharmacy, Medicinal Chemistry, Pharmaceutics +14

Synthesis and properties of 2′-O,4′-C-Ethylene-Bridged nucleic acids (ENA) as effective antisense oligonucleotides

Koji Morita, Miho Takagi, Chikako Hasegawa et al. · Bioorganic & Medicinal Chemistry · 2003 · 131 citations

Pharmacy, Chemistry, Molecular Biology +14

Effects on RNA Interference in Gene Expression (RNAi) in Cultured Mammalian Cells of Mismatches and the Introduction of Chemical Modifications at the 3′-Ends of siRNAs

Makiko Hamada, Toshiaki Ohtsuka, Reimi Kawaida et al. · Antisense and Nucleic Acid Drug Development · 2002 · 110 citations

Life Sciences, Genetics, Molecular Biology +15