Concepedia

Oligonucleotide Synthesis

Oligonucleotide Synthesis is a chemical process in nucleic acid engineering that belongs to the class of molecular fabrication techniques and is distinguished by its specific assembly of short, custom-designed sequences of nucleotides through phosphoramidite chemistry for applications in gene synthesis and genetic analysis.

3.9K

Publications

193.2K

Citations

8.5K

Authors

1.5K

Institutions

Publications per year

2017–2026

205

Parents

Publications

3.9K

Construction of improved M13 vectors using oligodeoxynucleotide-directed mutagenesis

Jan M. Norrander, Tomas Kempe, Joachim Messing · Gene · 1983 · 2.5K citations

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Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates

John F. Milligan, Duncan R. Groebe, Gary W. Witherell et al. · Nucleic Acids Research · 1987 · 2.2K citations · Full text

, , +12

Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis

Serge L. Beaucage, Marvin H. Caruthers · Tetrahedron Letters · 1981 · 2K citations

, , +7

Amplified RNA synthesized from limited quantities of heterogeneous cDNA.

Russell N. Van Gelder, M E von Zastrow, AJ Yool et al. · Proceedings of the National Academy of Sciences · 1990 · 1.3K citations

, , +11

Multivalent <i>N</i>-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

Jayaprakash K. Nair, Jennifer L. S. Willoughby, Amy Chan et al. · Journal of the American Chemical Society · 2014 · 1.1K citations

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1–5 of 3.9K

Authors

8.5K

  1. CB
    Colin B. Reese

    King's College London, United Kingdom

    54 publications · 2.8K citations

    30

    h-index

  2. HG
    H. G. Khorana

    Massachusetts Institute of Technology, United States

    39 publications · 3.1K citations

    30

    h-index

  3. MH
    Marvin H. Caruthers

    University of Colorado Boulder, United States

    48 publications · 5.8K citations

    29

    h-index

  4. RL
    Robert L. Letsinger

    Northwestern University, United States

    36 publications · 2.7K citations

    29

    h-index

  5. FS
    Frank Seela

    Osnabrück University, Germany

    66 publications · 2.3K citations

    28

    h-index

1–5 of 8.5K

Institutions

1.5K

  1. Centre National de la Recherche Scientifique

    Paris, France

    43 h-index

    561 publications

    22.7K citations

  2. Stanford University

    Stanford, United States

    36 h-index

    145 publications

    33.1K citations

  3. MRC Laboratory of Molecular Biology

    Cambridge, United Kingdom

    31 h-index

    126 publications

    8.5K citations

  4. Salk Institute for Biological Studies

    La Jolla, United States

    30 h-index

    102 publications

    7.8K citations

  5. Ionis Pharmaceuticals (United States)

    Carlsbad, United States

    30 h-index

    370 publications

    13K citations

  6. University of Colorado Boulder

    Boulder, United States

    29 h-index

    157 publications

    23.8K citations

  7. Osnabrück University

    Osnabrück, Germany

    28 h-index

    166 publications

    5.3K citations

  8. Harvard University

    Cambridge, United States

    27 h-index

    124 publications

    11.5K citations

1–8 of 1.5K

Venues

  1. Nucleic Acids Research

    455 publications · 30.5K citations

    89

    h-index

  2. Journal of the American Chemical Society

    JACS · 226 publications · 19.1K citations

    76

    h-index

  3. Journal of Biological Chemistry

    JBC · 96 publications · 12K citations

    57

    h-index

  4. Tetrahedron Letters

    368 publications · 14.2K citations

    50

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 68 publications · 9.7K citations

    49

    h-index

1–5