Jennifer L. S. Willoughby

Multivalent <i>N</i>-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

Jayaprakash K. Nair, Jennifer L. S. Willoughby, Amy Chan et al. · Journal of the American Chemical Society · 2014 · 1K citations

Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling

Samir Softic, Manoj K. Gupta, Guo-Xiao Wang et al. · Journal of Clinical Investigation · 2017 · 330 citations · Full text

Nutrition, Hepatic Lipogenesis, High-fat Diet +23

Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc–siRNA conjugates

Jayaprakash K. Nair, Husain Attarwala, Alfica Sehgal et al. · Nucleic Acids Research · 2017 · 258 citations · Full text

Pharmaceutical Science, Molecular Biology, Gene Delivery +16

Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins

Samir Softic, Jesse G. Meyer, Guo-Xiao Wang et al. · Cell Metabolism · 2019 · 220 citations · Full text

Biochemistry, Post-translational Modifications, Liver Physiology +9

siRNA Conjugates Carrying Sequentially Assembled Trivalent <i>N-</i>Acetylgalactosamine Linked Through Nucleosides Elicit Robust Gene Silencing <i>In Vivo</i> in Hepatocytes

Shigeo Matsuda, Kristofer Keiser, Jayaprakash K. Nair et al. · ACS Chemical Biology · 2015 · 206 citations