Jayaprakash K. Nair

Multivalent <i>N</i>-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

Jayaprakash K. Nair, Jennifer L. S. Willoughby, Amy Chan et al. · Journal of the American Chemical Society · 2014 · 1.1K citations

Pharmacy, Pharmaceutics, Pharmacology +17

An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia

Alfica Sehgal, Scott Barros, Lacramioara Ivanciu et al. · Nature Medicine · 2015 · 297 citations

Medicine, Hematology, Molecular Biology +12

Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates

Christopher R. Brown, Swati Gupta, June Qin et al. · Nucleic Acids Research · 2020 · 277 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +17

Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc–siRNA conjugates

Jayaprakash K. Nair, Husain Attarwala, Alfica Sehgal et al. · Nucleic Acids Research · 2017 · 270 citations · Full text

Pharmacy, Molecular Biology, Pharmacology +17

Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates

Kirk Brown, Jayaprakash K. Nair, Maja M. Janas et al. · Nature Biotechnology · 2022 · 245 citations

Pharmacy, Molecular Biology, Pharmacology +16