Concepedia

Christopher R. Brown

CR

Statistics

Publications

64

Citations

4.4K

H-Index

33

Active since

1983

Affiliations

Alnylam Pharmaceuticals (United States)(Current)

University of California, Santa Cruz

University of Cape Town

Harvard University

Rhodes University

Christopher R. Brown is an author at Alnylam Pharmaceuticals (United States) specializing in natural sciences, medicine, and molecular biology.

Top concepts

MedicineNatural SciencesBiologyMolecular BiologyEvolutionary BiologyEngineeringGeneticsGene ExpressionGene RegulationTranscriptional Regulation

Publications per year

1983–2024

64

Publications

64

Genome-Wide Localization of the Nuclear Transport Machinery Couples Transcriptional Status and Nuclear Organization

Jason M. Casolari, Christopher R. Brown, Suzanne Komili et al. · Cell · 2004 · 602 citations · Full text

Genome-wide Localization, Chromatin, Transcriptional Regulation +9

Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates

Donald J. Foster, Christopher R. Brown, Sarfraz Shaikh et al. · Molecular Therapy · 2018 · 294 citations · Full text

Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates

Christopher R. Brown, Swati Gupta, June Qin et al. · Nucleic Acids Research · 2020 · 265 citations · Full text

Sirna Accumulation, Molecular Pharmacology, Medicinal Chemistry +15

Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc–siRNA conjugates

Jayaprakash K. Nair, Husain Attarwala, Alfica Sehgal et al. · Nucleic Acids Research · 2017 · 258 citations · Full text

Pharmaceutical Science, Molecular Biology, Gene Delivery +16

Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates

Kirk Brown, Jayaprakash K. Nair, Maja M. Janas et al. · Nature Biotechnology · 2022 · 225 citations · Full text

Rnai Therapeutics, Liver Physiology, Gene Delivery +5

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