Interactions between Gut Microbiota, Host Genetics and Diet Modulate the Predisposition to Obesity and Metabolic Syndrome

Siegfried Ussar, Nicholas W. Griffin, Olivier Bézy, +7

Cell Metabolism

ObesityNutritionMetabolic SyndromeDysbiosisBody Composition +13

High-Fructose, Medium Chain Trans Fat Diet Induces Liver Fibrosis and Elevates Plasma Coenzyme Q9 in a Novel Murine Model of Obesity and Nonalcoholic Steatohepatitis†

Rohit Kohli, Michelle Kirby, Stavra A. Xanthakos, +9

Hepatology

Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway

Christopher L. Karp, Leah M. Flick, Kiwon W Park, +13

Nature Immunology

InflammationAnti-inflammatoryAllergyPulmonary PharmacologyPulmonary Fibrosis +2

Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling

Samir Softic, Manoj K. Gupta, Guo-Xiao Wang, +10

Journal of Clinical Investigation

NutritionHepatic LipogenesisHigh-fat DietCaloric RestrictionInsulin Signaling +21

IL-17 Signaling Accelerates the Progression of Nonalcoholic Fatty Liver Disease in Mice

Isaac T. W. Harley, Traci E. Stankiewicz, Daniel A. Giles, +10

Hepatology

Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling

Daniel A. Giles, Maria E. Moreno‐Fernandez, Traci E. Stankiewicz, +24

Nature Medicine

ObesityMetabolic SyndromeHepatologyLiver PhysiologyPhysiology +8

Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins

Samir Softic, Jesse G. Meyer, Guo-Xiao Wang, +14

Cell Metabolism

BiochemistryPost-translational ModificationsLiver PhysiologyPhysiologyMetabolic Regulation +7

Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation

Guoxiao Wang, Jesse G. Meyer, Weikang Cai, +6

Molecular Cell

Signal TransductionBiochemistryMitochondrial FunctionPhysiologyBrown Adipose Tissue +8

Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis

Brian T. O’Neill, Kevin Y. Lee, Katherine A. Klaus, +14

Journal of Clinical Investigation

Antibiotic effects on gut microbiota and metabolism are host dependent

Shiho Fujisaka, Siegfried Ussar, Clary B. Clish, +11

Journal of Clinical Investigation

DysbiosisHost-microbe InteractionsImmunologyGut MicrobiotaDrug Resistance +19