mTOR and S6K1 Mediate Assembly of the Translation Preinitiation Complex through Dynamic Protein Interchange and Ordered Phosphorylation Events

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

Do‐Hyung Kim, Dos D. Sarbassov, Siraj M. Ali et al. · Cell · 2002 · 3K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6k

Harold B.J. Jefferies, Stefano Fumagalli, Patrick B. Dennis et al. · The EMBO Journal · 1997 · 932 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +12

Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase

X. Wang · The EMBO Journal · 2001 · 794 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +7

<i>S6K1</i> ^−/− / <i>S6K2</i> ^−/− Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway

Mario Pende, Sung Hee Um, Virginie Mieulet et al. · Molecular and Cellular Biology · 2004 · 733 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

The Mammalian Target of Rapamycin (mTOR) Partner, Raptor, Binds the mTOR Substrates p70 S6 Kinase and 4E-BP1 through Their TOR Signaling (TOS) Motif

H Nojima, Chiharu Tokunaga, Satoshi Eguchi et al. · Journal of Biological Chemistry · 2003 · 681 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13