Concepedia

Mtor-dependent Initiation

mTOR-Dependent Initiation is a regulatory mechanism of eukaryotic translation initiation in which the activation of the mechanistic target of rapamycin (mTOR) kinase signaling pathway selectively enhances the assembly of the translation preinitiation complex at the 5' cap of mRNA, thereby promoting the recruitment of the small ribosomal subunit in a growth- and nutrient-sensitive manner.

31

Publications

5.1K

Citations

205

Authors

72

Institutions

Publications per year

2017–2026

4

Parents

Publications

31

mTOR and S6K1 Mediate Assembly of the Translation Preinitiation Complex through Dynamic Protein Interchange and Ordered Phosphorylation Events

Marina K. Holz, Bryan A. Ballif, Steven P. Gygi et al. · Cell · 2005 · 1.2K citations · Full text

, , +17

Metformin Inhibits Mammalian Target of Rapamycin–Dependent Translation Initiation in Breast Cancer Cells

Ryan J.O. Dowling, Mahvash Zakikhani, I. George Fantus et al. · Cancer Research · 2007 · 929 citations · Full text

, , +12

Leucine Stimulates Translation Initiation in Skeletal Muscle of Postabsorptive Rats via a Rapamycin-Sensitive Pathway

Joshua C. Anthony, Fumiaki Yoshizawa, Tracy G. Anthony et al. · Journal of Nutrition · 2000 · 796 citations

, , +17

BDNF Activates mTOR to Regulate GluR1 Expression Required for Memory Formation

Leandro Slipczuk, Pedro Bekinschtein, Cynthia Katche et al. · PLoS ONE · 2009 · 248 citations · Full text

, , +17

Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model

Sara Ricciardi, Elena Boggio, Stefano Grosso et al. · Human Molecular Genetics · 2011 · 225 citations · Full text

, , +17

1–5 of 31

Authors

205

  1. LS
    Leonard S. Jefferson

    Pennsylvania State University, United States

    4 publications · 1.2K citations

    4

    h-index

  2. HV
    Hanh V. Nguyen

    Children's Nutrition Research Center at Baylor College of Medicine, United States

    3 publications · 211 citations

    3

    h-index

  3. SR
    Scot R. Kimball

    Pennsylvania State University, United States

    3 publications · 992 citations

    3

    h-index

  4. TC
    Thomas C. Vary

    Pennsylvania State University, United States

    3 publications · 1K citations

    3

    h-index

  5. NS
    Nahum Sonenberg

    McGill University, Canada

    3 publications · 1.1K citations

    3

    h-index

1–5 of 205

Institutions

72

  1. Pennsylvania State University

    State College, United States

    6 h-index

    23 publications

    6.6K citations

  2. University of Toronto

    Toronto, Canada

    4 h-index

    8 publications

    1.3K citations

  3. McGill University

    Montreal, Canada

    4 h-index

    19 publications

    2.7K citations

  4. Harvard University

    Cambridge, United States

    3 h-index

    11 publications

    5.7K citations

  5. Dana-Farber Cancer Institute

    Boston, United States

    2 h-index

    9 publications

    828 citations

  6. Baylor College of Medicine

    Houston, United States

    2 h-index

    18 publications

    676 citations

  7. University of Rome Tor Vergata

    Rome, Italy

    2 h-index

    13 publications

    364 citations

  8. University of Illinois Urbana-Champaign

    Urbana, United States

    2 h-index

    6 publications

    544 citations

1–8 of 72

Venues

  1. Journal of Biological Chemistry

    JBC · 5 publications · 489 citations

    5

    h-index

  2. 3

    h-index

  3. Cancer Research

    2 publications · 1K citations

    2

    h-index

  4. Journal of Nutrition

    JN · 2 publications · 923 citations

    2

    h-index

  5. Cell Reports

    2 publications · 146 citations

    2

    h-index

1–5