Cell · 2013 · 307 citations · 49 references
Life SciencesMolecular BiologyCell SignalingMolecular BiophysicsSignal TransductionAllosteric ModulationAllosteric RecognitionAllosteric RegulationCell Signaling NetworksProtein Kinase CascadesReceptor Tyrosine Kinase SignalingAllosteric ActivationAllosteric Activation MechanismsAllosteric Enzyme ActivationAllosteric Regulation Of DimerizationRaf Signaling
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Mutations of the BRAF gene in human cancer
Helen Davies, Graham R. Bignell, Charles Cox et al. · Nature · 2002 · 10.7K citations
Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF
Paul Wan, Mathew J. Garnett, S. Mark Roe et al. · Cell · 2004 · 2.8K citations · Full text
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
Poulikos I. Poulikakos, Chao Zhang, Gideon Bollag et al. · Nature · 2010 · 1.8K citations · Full text
An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor
Xuewu Zhang, Jodi Gureasko, Kui Shen et al. · Cell · 2006 · 1.6K citations · Full text
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
Georgia Hatzivassiliou, Kyung Song, Ivana Yen et al. · Nature · 2010 · 1.6K citations
Medicine, Cancer Biology, Oncology +15