Concepedia

Discovery and characterization of AZD9272 and AZD6538—Two novel mGluR5 negative allosteric modulators selected for clinical development

Patrick Raboisson, Anna Breitholtz‐Emanuelsson, Henrik Dahllöf, Louise Edwards, William L. Heaton, Methvin Isaac, Keith R. Jarvie, Annika Kers, Alexander B. E. Minidis, Anna Nordmark,

Bioorganic & Medicinal Chemistry Letters · 2012 · 38 citations · 26 references

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26

The rat brain in stereotaxic coordinates

Miklós Palkovits · Neuropeptides · 1983 · 29K citations

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2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

F. Gasparini, Kurt Lingenhöhl, Natacha Stoehr et al. · Neuropharmacology · 1999 · 720 citations

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Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain

Carmelo Romano, Michael A. Sesma, Colin T. McDonald et al. · The Journal of Comparative Neurology · 1995 · 673 citations

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Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice

Cristiano Chiamulera, Mark P. Epping-Jordan, Alessandro Zocchi et al. · Nature Neuroscience · 2001 · 549 citations

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3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]- pyridine:  A Potent and Highly Selective Metabotropic Glutamate Subtype 5 Receptor Antagonist with Anxiolytic Activity

Nicholas D. P. Cosford, Lida Tehrani, Jeffrey Roppe et al. · Journal of Medicinal Chemistry · 2002 · 400 citations · Full text

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