Regulation of p53 stability by Mdm2

Michael H.G. Kubbutat, Stephen N. Jones, Karen H. Vousden

Nature

Tumor BiologyTumor SuppressorMedicineCell BiologyCancer Research +1

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

Yunje Cho, Svetlana S. Gorina, Philip D. Jeffrey, +1

Science

ChromatinCrystal StructureDna BindingStructural BioinformaticsBiomolecular Structure Prediction +13

International Zinc Nutrition Consultative Group (IZiNCG) technical document #1. Assessment of the risk of zinc deficiency in populations and options for its control.

Kenneth H. Brown, Juan Á. Rivera, Zulfiqar A Bhutta, +7

PubMed

NutritionNutritional RequirementGlobal HealthNutrition DevelopmentInternational Health +12

Structure-Based Design of Spiro-oxindoles as Potent, Specific Small-Molecule Inhibitors of the MDM2−p53 Interaction

Ke Ding, Yipin Lu, Zaneta Nikolovska‐Coleska, +9

Journal of Medicinal Chemistry

Combinatorial ChemistryMdm2-p53 InteractionChemoprevention StrategyChemical BiologyP53 Function +17

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

Sanjeev Shangary, Dongguang Qin, Donna McEachern, +18

Proceedings of the National Academy of Sciences

Structure-Based Design of Potent Non-Peptide MDM2 Inhibitors

Ke Ding, Yipin Lu, Zaneta Nikolovska‐Coleska, +10

Journal of the American Chemical Society

Molecular DockingMedicinal ChemistryDrug TargetDrug DesignNatural P53 Peptide +13

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots.

Nikola P. Pavletich, Kristen A Chambers, Carl O. Pabo

Genes & Development

Correlation of apoptosis with change in intracellular labile Zn(II) using zinquin [(2-methyl-8-<i>p</i>-toluenesulphonamido-6-quinolyloxy)acetic acid], a new specific fluorescent probe for Zn(II)

Peter D. Zalewski, Ian J. Forbes, W H Betts

Biochemical Journal

Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFκB, and AP1 DNA binding, and affects DNA repair in a rat glioma cell line

Emily Ho, Bruce N. Ames

Proceedings of the National Academy of Sciences

The cell cycle and cancer

Kathleen Collins, Tyler Jacks, Nikola P. Pavletich

Proceedings of the National Academy of Sciences

Climate EthicsEngineeringClimate PolicyEnvironmental EconomicsCell Cycle +22