MI-219-zinc combination: a new paradigm in MDM2 inhibitor-based therapy

Regulation of p53 stability by Mdm2

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Tumor Biology, Tumor Suppressor, Medicine +3

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

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Chromatin, Crystal Structure, Dna Binding +15

International Zinc Nutrition Consultative Group (IZiNCG) technical document #1. Assessment of the risk of zinc deficiency in populations and options for its control.

Kenneth H. Brown, Juan Á. Rivera, Zulfiqar A Bhutta et al. · PubMed · 2004 · 1.1K citations

Nutrition, Nutritional Requirement, Global Health +14

Structure-Based Design of Spiro-oxindoles as Potent, Specific Small-Molecule Inhibitors of the MDM2−p53 Interaction

Ke Ding, Yipin Lu, Zaneta Nikolovska‐Coleska et al. · Journal of Medicinal Chemistry · 2006 · 681 citations · Full text

Combinatorial Chemistry, Mdm2-p53 Interaction, Chemoprevention Strategy +19

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

Sanjeev Shangary, Dongguang Qin, Donna McEachern et al. · Proceedings of the National Academy of Sciences · 2008 · 650 citations · Full text