Dongguang Qin

Structure-Based Design of Spiro-oxindoles as Potent, Specific Small-Molecule Inhibitors of the MDM2−p53 Interaction

Ke Ding, Yipin Lu, Zaneta Nikolovska‐Coleska et al. · Journal of Medicinal Chemistry · 2006 · 692 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

Sanjeev Shangary, Dongguang Qin, Donna McEachern et al. · Proceedings of the National Academy of Sciences · 2008 · 656 citations · Full text

Medicine, Oncology, Pharmacology +13

Potent and Orally Active Small-Molecule Inhibitors of the MDM2−p53 Interaction

Shanghai Yu, Dongguang Qin, Sanjeev Shangary et al. · Journal of Medicinal Chemistry · 2009 · 177 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Discovery of a Nanomolar Inhibitor of the Human Murine Double Minute 2 (MDM2)−p53 Interaction through an Integrated, Virtual Database Screening Strategy

Yipin Lu, Zaneta Nikolovska‐Coleska, Xueliang Fang et al. · Journal of Medicinal Chemistry · 2006 · 115 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Structure-Based Design, Synthesis, Evaluation, and Crystallographic Studies of Conformationally Constrained Smac Mimetics as Inhibitors of the X-linked Inhibitor of Apoptosis Protein (XIAP)

Haiying Sun, Jeanne A. Stuckey, Zaneta Nikolovska‐Coleska et al. · Journal of Medicinal Chemistry · 2008 · 82 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12