Structure-Based Design of Spiro-oxindoles as Potent, Specific Small-Molecule Inhibitors of the MDM2−p53 Interaction

Ke Ding, Yipin Lu, Zaneta Nikolovska‐Coleska, +9

Journal of Medicinal Chemistry

Combinatorial ChemistryMdm2-p53 InteractionChemoprevention StrategyChemical BiologyP53 Function +17

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

Sanjeev Shangary, Dongguang Qin, Donna McEachern, +18

Proceedings of the National Academy of Sciences

Potent and Orally Active Small-Molecule Inhibitors of the MDM2−p53 Interaction

Shanghai Yu, Dongguang Qin, Sanjeev Shangary, +9

Journal of Medicinal Chemistry

Discovery of a Nanomolar Inhibitor of the Human Murine Double Minute 2 (MDM2)−p53 Interaction through an Integrated, Virtual Database Screening Strategy

Yipin Lu, Zaneta Nikolovska‐Coleska, Xueliang Fang, +5

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryMdm2-p53 InteractionDrug TargetDrug Targeting +13

Structure-Based Design, Synthesis, Evaluation, and Crystallographic Studies of Conformationally Constrained Smac Mimetics as Inhibitors of the X-linked Inhibitor of Apoptosis Protein (XIAP)

Haiying Sun, Jeanne A. Stuckey, Zaneta Nikolovska‐Coleska, +7

Journal of Medicinal Chemistry

X-ray CrystallographyCrystal StructureApoptosis ProteinMolecular BiologyChemical Biology +16

Synthesis of [1,2,3]Triazolo[1,5-<i>a</i>]quinoxalin-4(5<i>H</i>)-ones through Copper-Catalyzed Tandem Reactions of <i>N</i>-(2-Haloaryl)propiolamides with Sodium Azide

Jiajie Yan, Fengtao Zhou, Dongguang Qin, +3

Organic Letters

Design and characterization of bivalent Smac-based peptides as antagonists of XIAP and development and validation of a fluorescence polarization assay for XIAP containing both BIR2 and BIR3 domains

Zaneta Nikolovska‐Coleska, Jennifer L. Meagher, Sheng Jiang, +7

Analytical Biochemistry

Bir3 DomainsBivalent Smac-based PeptidesBiochemistryMedicinePeptide Engineering +6

Design, Synthesis, and Evaluation of Potent, Nonpeptidic Mimetics of Second Mitochondria-Derived Activator of Caspases

Wei Sun, Zaneta Nikolovska‐Coleska, Dongguang Qin, +7

Journal of Medicinal Chemistry

Studies on the Synthesis of (2<i>S</i>,3<i>R</i>)-3-Hydroxy-3-methylproline via C₂−N Bond Formation

Junwei Shen, Dongguang Qin, Hongwang Zhang, +1

The Journal of Organic Chemistry

Structure-Based Design of Potent Nicotinamide Phosphoribosyltransferase Inhibitors with Promising in Vitro and in Vivo Antitumor Activities

Jinhong Bai, Chenzhong Liao, Yanghan Liu, +7

Journal of Medicinal Chemistry

Bioorganic ChemistryPharmacotherapyChemical BiologyMedicinal ChemistryStructure-based Design +14