Structure-Based Design of Spiro-oxindoles as Potent, Specific Small-Molecule Inhibitors of the MDM2−p53 Interaction

Ke Ding, Yipin Lu, Zaneta Nikolovska‐Coleska, +9

Journal of Medicinal Chemistry

Combinatorial ChemistryMdm2-p53 InteractionChemoprevention StrategyChemical BiologyP53 Function +17

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

Sanjeev Shangary, Dongguang Qin, Donna McEachern, +18

Proceedings of the National Academy of Sciences

SAR405838: An Optimized Inhibitor of MDM2–p53 Interaction That Induces Complete and Durable Tumor Regression

Shaomeng Wang, Wei Sun, Yujun Zhao, +19

Cancer Research

Structure-Based Design of Potent Small-Molecule Inhibitors of Anti-Apoptotic Bcl-2 Proteins

Guoping Wang, Zaneta Nikolovska‐Coleska, Chao‐Yie Yang, +15

Journal of Medicinal Chemistry

SM-164: A Novel, Bivalent Smac Mimetic That Induces Apoptosis and Tumor Regression by Concurrent Removal of the Blockade of cIAP-1/2 and XIAP

Jianfeng Lü, Longchuan Bai, Haiying Sun, +10

Cancer Research

Tumor RegressionApoptosis ProteinApoptosisImmunologyCell Death +16

Potent and Orally Active Small-Molecule Inhibitors of the MDM2−p53 Interaction

Shanghai Yu, Dongguang Qin, Sanjeev Shangary, +9

Journal of Medicinal Chemistry

Discovery of a Nanomolar Inhibitor of the Human Murine Double Minute 2 (MDM2)−p53 Interaction through an Integrated, Virtual Database Screening Strategy

Yipin Lu, Zaneta Nikolovska‐Coleska, Xueliang Fang, +5

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryMdm2-p53 InteractionDrug TargetDrug Targeting +13

Peptides Derived from BH3 Domains of Bcl-2 Family Members:  A Comparative Analysis of Inhibition of Bcl-2, Bcl-x_L and Bax Oligomerization, Induction of Cytochrome <i>c</i> Release, and Activation of Cell Death

Sanjeev Shangary, Daniel E. Johnson

Biochemistry

Amino AcidsChemoprevention StrategyApoptosisImmunologyCell Death +22

Comprehensive biomarker and genomic analysis identifies p53 status as the major determinant of response to MDM2 inhibitors in chronic lymphocytic leukemia

Chris Saddler, Peter Ouillette, Lisa Kujawski, +7

Blood

Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer

Sanjeev Shangary, Ke Ding, Su Qiu, +10

Molecular Cancer Therapeutics

P53 StatusP53 DependentCell DeathCancer BiologyTumor Biology +16