Concepedia

Regulation of p53 stability by Mdm2

Michael H.G. Kubbutat, Stephen N. Jones, Karen H. Vousden

Nature · 1997 · 3.3K citations · 29 references

DOI

Concepts

References

29

Mdm2 promotes the rapid degradation of p53

Ygal Haupt, Ruth Maya, Anat Kazaz et al. · Nature · 1997 · 4.5K citations

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The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

Martin Scheffner, Bruce A. Werness, Jon M. Huibregtse et al. · Cell · 1990 · 4K citations

, , +14

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

Jamil Momand, Gerard P. Zambetti, David C. Olson et al. · Cell · 1992 · 3.1K citations

, , +10

The p53-mdm-2 autoregulatory feedback loop.

J. Henri Bayle, David C. Olson, Arnold J. Levine · Genes & Development · 1993 · 1.8K citations · Full text

, , +14

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

Gabriel Fenteany, Robert F. Standaert, William S. Lane et al. · Science · 1995 · 1.6K citations

, , +15