Jon M. Huibregtse

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

Martin Scheffner, Bruce A. Werness, Jon M. Huibregtse et al. · Cell · 1990 · 4K citations

Human Papillomavirus Vaccines, Medicine, Pathology +10

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

Martin Scheffner, Jon M. Huibregtse, Richard D. Vierstra et al. · Cell · 1993 · 2.4K citations

Hpv-16 E6, Ubiquitin-protein Ligase, Protein Function +4

Protein ubiquitination involving an E1–E2–E3 enzyme ubiquitin thioester cascade

Martin Scheffner, Ulrike A. Nuber, Jon M. Huibregtse · Nature · 1995 · 1K citations

Protein Chemistry, Protein Function, Biochemistry +5

A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18.

Jon M. Huibregtse, Martin Scheffner, Peter M. Howley · The EMBO Journal · 1991 · 879 citations · Full text

Medicine, Pathology, E6 Oncoprotein +10

Structure of an E6AP-UbcH7 Complex: Insights into Ubiquitination by the E2-E3 Enzyme Cascade

Lan Huang, E. Kinnucan, Guangli Wang et al. · Science · 1999 · 556 citations

Crystal Structure, Protein Assembly, Structural Bioinformatics +18