Concepedia

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

Martin Scheffner, Jon M. Huibregtse, Richard D. Vierstra, Peter M. Howley

Cell · 1993 · 2.4K citations · 50 references

DOI

Concepts

References

50

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

Martin Scheffner, Bruce A. Werness, Jon M. Huibregtse et al. · Cell · 1990 · 4K citations

, , +14

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

Michael B. Kastan, Qimin Zhan, Wafik S. El‐Deiry et al. · Cell · 1992 · 3.1K citations

, , +12

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

Nicholas J. Dyson, Peter M. Howley, Karl Münger et al. · Science · 1989 · 3.1K citations

, , +17

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

Bruce A. Werness, Arnold J. Levine, Peter M. Howley · Science · 1990 · 2.6K citations

, , +17

T antigen is bound to a host protein in SY40-transformed cells

David P. Lane, L.V. Crawford · Nature · 1979 · 2.4K citations

, , +10