Concepedia

E6 Oncoprotein

E6 Oncoprotein is an oncoprotein, belonging to the class of viral regulatory proteins encoded by high-risk human papillomaviruses, that functionally inactivates the host tumor suppressor protein p53 through targeted ubiquitin-mediated degradation, thereby promoting cellular immortalization and oncogenesis.

1.5K

Publications

112.5K

Citations

6.6K

Authors

1.5K

Institutions

Publications per year

2017–2026

272

Parents

Publications

1.5K

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

Martin Scheffner, Bruce A. Werness, Jon M. Huibregtse et al. · Cell · 1990 · 4K citations

, , +14

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

Bruce A. Werness, Arnold J. Levine, Peter M. Howley · Science · 1990 · 2.6K citations

, , +17

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

Martin Scheffner, Jon M. Huibregtse, Richard D. Vierstra et al. · Cell · 1993 · 2.4K citations

, , +15

The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes

Karl Münger, William C. Phelps, Vivien J. Bubb et al. · Journal of Virology · 1989 · 1.3K citations · Full text

, , +15

Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma

Cristina E. Tognon, Stevan R. Knezevich, David G. Huntsman et al. · Cancer Cell · 2002 · 905 citations · Full text

, , +16

1–5 of 1.5K

Authors

6.6K

  1. LB
    Lawrence Banks

    International Centre for Genetic Engineering and Biotechnology, Italy

    78 publications · 6.2K citations

    46

    h-index

  2. PM
    Peter M. Howley

    Harvard University, United States

    38 publications · 17.7K citations

    36

    h-index

  3. GT
    Gilles Travé

    Centre National de la Recherche Scientifique, France

    38 publications · 2.4K citations

    28

    h-index

  4. EJ
    Elliot J. Androphy

    University of Massachusetts Chan Medical School, United States

    32 publications · 2.4K citations

    28

    h-index

  5. PF
    Paul F. Lambert

    University of Wisconsin–Madison, United States

    30 publications · 2.9K citations

    28

    h-index

1–5 of 6.6K

Institutions

1.5K

  1. International Centre for Genetic Engineering and Biotechnology

    Trieste, Italy

    45 h-index

    193 publications

    15.9K citations

  2. National Cancer Institute

    Bethesda, United States

    44 h-index

    168 publications

    56.9K citations

  3. Harvard University

    Cambridge, United States

    39 h-index

    140 publications

    16.7K citations

  4. German Cancer Research Center

    Heidelberg, Germany

    36 h-index

    255 publications

    19.3K citations

  5. Fred Hutch Cancer Center

    Seattle, United States

    32 h-index

    119 publications

    16K citations

  6. University of Wisconsin–Madison

    Madison, United States

    32 h-index

    119 publications

    13.2K citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    31 h-index

    223 publications

    14.1K citations

  8. DKFZ-ZMBH Alliance

    Heidelberg, Germany

    31 h-index

    131 publications

    12.4K citations

1–8 of 1.5K

Venues

  1. Journal of Virology

    JVI · 205 publications · 20.1K citations

    79

    h-index

  2. PubMed

    Repository · 112 publications · 8.2K citations

    53

    h-index

  3. Oncogene

    58 publications · 5.4K citations

    39

    h-index

  4. Virology

    67 publications · 3.2K citations

    37

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 39 publications · 7.1K citations

    36

    h-index

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