Optimization of orally bioavailable alkyl amine renin inhibitors

Generation of a Set of Simple, Interpretable ADMET Rules of Thumb

M. Paul Gleeson · Journal of Medicinal Chemistry · 2008 · 961 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

A stable and easily prepared catalyst for the enantioselective reduction of ketones. Applications to multistep syntheses

E. J. Corey, Raman K. Bakshi, Saizo Shibata et al. · Journal of the American Chemical Society · 1987 · 864 citations

Natural Sciences, Chemistry, Catalysis +15

Matched Molecular Pairs as a Guide in the Optimization of Pharmaceutical Properties; a Study of Aqueous Solubility, Plasma Protein Binding and Oral Exposure

Andrew G. Leach, Huw Jones, David A. Cosgrove et al. · Journal of Medicinal Chemistry · 2006 · 283 citations

Pharmacy, Medicinal Chemistry, Pharmacology +16

Species specificity of renin kinetics in transgenic rats harboring the human renin and angiotensinogen genes.

Detlev Ganten, J. Wagner, Karin Zeh et al. · Proceedings of the National Academy of Sciences · 1992 · 234 citations

Life Sciences, Biochemistry, Physiology +17

Structural Modification of the P2‘ Position of 2,7-Dialkyl-Substituted 5( <i>S</i> )-Amino-4( <i>S</i> )-hydroxy-8-phenyl-octanecarboxamides:  The Discovery of Aliskiren, a Potent Nonpeptide Human Renin Inhibitor Active after Once Daily Dosing in Marmosets

Jürgen Maibaum, Stefan Stutz, Richard Göschke et al. · Journal of Medicinal Chemistry · 2007 · 95 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13