Concepedia

Oral Bioavailability Optimization

Oral Bioavailability Optimization is a strategic research endeavor in drug discovery that systematically enhances the fraction and rate of an administered drug reaching systemic circulation following oral ingestion, by simultaneously improving solubility, permeability, and metabolic stability while minimizing efflux and gastrointestinal degradation.

819

Publications

40K

Citations

4.9K

Authors

962

Institutions

Publications per year

2017–2026

358

Parents

Publications

819

Particle size reduction for improvement of oral bioavailability of hydrophobic drugs: I. Absolute oral bioavailability of nanocrystalline danazol in beagle dogs

Gary G. Liversidge, Kenneth C. Cundy · International Journal of Pharmaceutics · 1995 · 737 citations

, , +17

Use of a Glutaric Acid Cocrystal to Improve Oral Bioavailability of a Low Solubility API

Daniel P. McNamara, S.L. Childs, Jennifer Giordano et al. · Pharmaceutical Research · 2006 · 687 citations

, , +16

Innovative Preparation of Curcumin for Improved Oral Bioavailability

Hiroki Sasaki, Yoichi Sunagawa, Kenji Takahashi et al. · Biological and Pharmaceutical Bulletin · 2011 · 443 citations · Full text

, , +16

1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity

Susan M. Daluge, Steven S. Good, M B Faletto et al. · Antimicrobial Agents and Chemotherapy · 1997 · 385 citations · Full text

, , +15

Using the Golden Triangle to optimize clearance and oral absorption

Ted W. Johnson, Klaus Dress, Martin P. Edwards · Bioorganic & Medicinal Chemistry Letters · 2009 · 382 citations

, , +14

1–5 of 819

Authors

4.9K

  1. JY
    Jiangnan Yu

    Jiangsu University, China

    15 publications · 727 citations

    15

    h-index

  2. HC
    Han‐Gon Choi

    Hanyang University, South Korea

    15 publications · 674 citations

    14

    h-index

  3. XX
    Ximing Xu

    Jiangsu University, China

    14 publications · 690 citations

    14

    h-index

  4. JO
    Jong Oh Kim

    Yeungnam University, South Korea

    14 publications · 637 citations

    11

    h-index

  5. MA
    Michael Adu‐Frimpong

    Jiangsu University, China

    9 publications · 299 citations

    9

    h-index

1–5 of 4.9K

Institutions

962

  1. Shenyang Pharmaceutical University

    Shenyang, China

    20 h-index

    156 publications

    5.4K citations

  2. Cairo University

    Giza, Egypt

    19 h-index

    52 publications

    2.3K citations

  3. King Saud University

    Riyadh, Saudi Arabia

    15 h-index

    48 publications

    1.9K citations

  4. Jiangsu University

    Zhenjiang, China

    15 h-index

    123 publications

    6.4K citations

  5. Chungnam National University

    Daejeon, South Korea

    14 h-index

    77 publications

    3.8K citations

  6. Hanyang University

    Seoul, South Korea

    13 h-index

    48 publications

    1.8K citations

  7. Jamia Hamdard

    New Delhi, India

    13 h-index

    42 publications

    1.8K citations

  8. Yeungnam University

    Daegu, South Korea

    12 h-index

    91 publications

    4.1K citations

1–8 of 962

Venues

  1. International Journal of Pharmaceutics

    68 publications · 4.7K citations

    41

    h-index

  2. Journal of Medicinal Chemistry

    65 publications · 4K citations

    38

    h-index

  3. AAPS PharmSciTech

    44 publications · 1.8K citations

    25

    h-index

  4. European Journal of Pharmaceutical Sciences

    31 publications · 1.8K citations

    24

    h-index

  5. Drug Development and Industrial Pharmacy

    37 publications · 1.6K citations

    24

    h-index

1–5