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Novel scaffold for cathepsin K inhibitors

Naoki Teno, Takahiro Miyake, Takeru Ehara, Osamu Irie, Junichi Sakaki, Osamu Ohmori, Hiroki Gunji, Naoko Matsuura, Keiichi Masuya, Yuko Hitomi,

Bioorganic & Medicinal Chemistry Letters · 2007 · 41 citations · 11 references

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11

Structure-Activity Relationships for Inhibition of Farnesyl Diphosphate Synthase in Vitro and Inhibition of Bone Resorption in Vivo by Nitrogen-Containing Bisphosphonates

James E. Dunford, Keith Thompson, Fraser P. Coxon et al. · Journal of Pharmacology and Experimental Therapeutics · 2001 · 896 citations

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Cathepsin K, but Not Cathepsins B, L, or S, Is Abundantly Expressed in Human Osteoclasts

Fred H. Drake, Robert A. Dodds, Ian E. James et al. · Journal of Biological Chemistry · 1996 · 716 citations · Full text

, , +11

The Substitution of Aryl Iodides with Cuprous Acetylides. A Synthesis of Tolanes and Heterocyclics<sup>1</sup>

Robert D. Stephens, C. E. Castro · The Journal of Organic Chemistry · 1963 · 623 citations

, , +7

Farnesyl Pyrophosphate Synthase Is the Molecular Target of Nitrogen-Containing Bisphosphonates

Ermond van Beek, Elsbet Pieterman, Louis Cohen et al. · Biochemical and Biophysical Research Communications · 1999 · 503 citations

, , +6

Human Cathepsin O2, a Matrix Protein-degrading Cysteine Protease Expressed in Osteoclasts

Dieter Brömme, Kathleen Okamoto, Bruce B. Wang et al. · Journal of Biological Chemistry · 1996 · 425 citations · Full text

, , +17