Farnesyl Pyrophosphate Synthase Is the Molecular Target of Nitrogen-Containing Bisphosphonates

Nitrogen-Containing Bisphosphonates Inhibit the Mevalonate Pathway and Prevent Post-Translational Prenylation of GTP-Binding Proteins, Including Ras

Steven P. Luckman, D. E. Hughes, Fraser P. Coxon et al. · Journal of Bone and Mineral Research · 1998 · 1.2K citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation <i>in vitro</i>

John Fisher, Michael J. Rogers, J. M. Halasy et al. · Proceedings of the National Academy of Sciences · 1999 · 679 citations

Medicine, Biochemistry, Pharmacology +17

Bisphosphonates used for the treatment of bone disorders inhibit squalene synthase and cholesterol biosynthesis.

Dilip Amin, SA Cornell, SK Gustafson et al. · Journal of Lipid Research · 1992 · 283 citations · Full text

Life Sciences, Biochemistry, Pharmacology +14

The Role of Geranylgeranylation in Bone Resorption and Its Suppression by Bisphosphonates in Fetal Bone Explants In Vitro: A Clue to the Mechanism of Action of Nitrogen-Containing Bisphosphonates

Ermond van Beek, Clemens W.G.M. Löwik, Gabri van der Pluijm et al. · Journal of Bone and Mineral Research · 1999 · 240 citations

Medicine, Pharmacology, Bone Metabolism +16

A protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificity.

Kohei Yokoyama, Gary W. Goodwin, Farideh Ghomashchi et al. · Proceedings of the National Academy of Sciences · 1991 · 222 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +7