Concepedia

Farnesyl Diphosphate Synthase

Farnesyl Diphosphate Synthase is an enzyme in the terpenoid biosynthesis pathway that catalyzes the sequential condensation of isopentenyl diphosphate with dimethylallyl diphosphate to form farnesyl diphosphate, a key intermediate in cholesterol biosynthesis.

956

Publications

58.4K

Citations

4K

Authors

991

Institutions

Publications per year

2017–2026

188

Variants

Farnesyl Pyrophosphate SynthaseFpps

Parents

Publications

956

Structure-Activity Relationships for Inhibition of Farnesyl Diphosphate Synthase in Vitro and Inhibition of Bone Resorption in Vivo by Nitrogen-Containing Bisphosphonates

James E. Dunford, Keith Thompson, Fraser P. Coxon et al. · Journal of Pharmacology and Experimental Therapeutics · 2001 · 896 citations

, , +17

Structural Basis for Cyclic Terpene Biosynthesis by Tobacco 5-Epi-Aristolochene Synthase

Courtney M. Starks, Kyoungwhan Back, Joseph Chappell et al. · Science · 1997 · 738 citations

, , +17

The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs

K.L. Kavanagh, Kunde Guo, James E. Dunford et al. · Proceedings of the National Academy of Sciences · 2006 · 532 citations · Full text

, , +17

Farnesyl Pyrophosphate Synthase Is the Molecular Target of Nitrogen-Containing Bisphosphonates

Ermond van Beek, Elsbet Pieterman, Louis Cohen et al. · Biochemical and Biophysical Research Communications · 1999 · 503 citations

, , +6

Genomic Organization of Plant Terpene Synthases and Molecular Evolutionary Implications

Susan Trapp, Rodney Croteau · Genetics · 2001 · 482 citations

, , +17

1–5 of 956

Authors

4K

  1. DE
    David E. Cane

    Brown University, United States

    42 publications · 4K citations

    36

    h-index

  2. EO
    Eric Oldfield

    University of Illinois Urbana-Champaign, United States

    49 publications · 2.9K citations

    32

    h-index

  3. CD
    C. Dale Poulter

    University of Utah, United States

    43 publications · 4.1K citations

    31

    h-index

  4. RK
    Rudolf K. Allemann

    Cardiff University, United Kingdom

    28 publications · 1.1K citations

    22

    h-index

  5. DW
    David W. Christianson

    University of Pennsylvania, United States

    18 publications · 1.9K citations

    18

    h-index

1–5 of 4K

Institutions

991

  1. University of Illinois Urbana-Champaign

    Urbana, United States

    37 h-index

    301 publications

    20.2K citations

  2. Brown University

    Providence, United States

    31 h-index

    94 publications

    10.2K citations

  3. University of Utah

    Salt Lake City, United States

    29 h-index

    103 publications

    8K citations

  4. Tohoku University

    Sendai, Japan

    24 h-index

    159 publications

    9.4K citations

  5. Chinese Academy of Sciences

    Beijing, China

    23 h-index

    112 publications

    10.3K citations

  6. Institute of Biological Chemistry, Academia Sinica

    Taipei, Taiwan

    22 h-index

    112 publications

    7.4K citations

  7. Cardiff University

    Cardiff, United Kingdom

    22 h-index

    113 publications

    4.9K citations

  8. Washington State University

    Pullman, United States

    19 h-index

    56 publications

    7.3K citations

1–8 of 991

Venues

  1. Journal of Biological Chemistry

    JBC · 70 publications · 7.3K citations

    55

    h-index

  2. Journal of the American Chemical Society

    JACS · 52 publications · 3.1K citations

    36

    h-index

  3. Biochemistry

    36 publications · 2.2K citations

    25

    h-index

  4. Journal of Medicinal Chemistry

    26 publications · 1.3K citations

    24

    h-index

  5. PLANT PHYSIOLOGY

    24 publications · 1.9K citations

    22

    h-index

1–5