James E. Dunford

Structure-Activity Relationships for Inhibition of Farnesyl Diphosphate Synthase in Vitro and Inhibition of Bone Resorption in Vivo by Nitrogen-Containing Bisphosphonates

James E. Dunford, Keith Thompson, Fraser P. Coxon et al. · Journal of Pharmacology and Experimental Therapeutics · 2001 · 896 citations

Medicine, Medicinal Chemistry, Pharmacology +17

The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs

K.L. Kavanagh, Kunde Guo, James E. Dunford et al. · Proceedings of the National Academy of Sciences · 2006 · 532 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Inhibition of Protein Prenylation by Bisphosphonates Causes Sustained Activation of Rac, Cdc42, and Rho GTPases

James E. Dunford, Michael J. Rogers, Frank H. Ebetino et al. · Journal of Bone and Mineral Research · 2006 · 187 citations · Full text

Medicine, Cell Biology, Pharmacology +15

The Crystal Structure of Human Geranylgeranyl Pyrophosphate Synthase Reveals a Novel Hexameric Arrangement and Inhibitory Product Binding

K.L. Kavanagh, James E. Dunford, G. Bunkóczi et al. · Journal of Biological Chemistry · 2006 · 165 citations · Full text

Life Sciences, Biochemistry, Biology +11

Identification of a Novel Phosphonocarboxylate Inhibitor of Rab Geranylgeranyl Transferase That Specifically Prevents Rab Prenylation in Osteoclasts and Macrophages

Fraser P. Coxon, Miep Helfrich, Banafshé Larijani et al. · Journal of Biological Chemistry · 2001 · 160 citations · Full text

Medicine, Biochemistry, Pharmacology +17