Structure-Activity Relationships for Inhibition of Farnesyl Diphosphate Synthase in Vitro and Inhibition of Bone Resorption in Vivo by Nitrogen-Containing Bisphosphonates

Nitrogen-Containing Bisphosphonates Inhibit the Mevalonate Pathway and Prevent Post-Translational Prenylation of GTP-Binding Proteins, Including Ras

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Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo

D. E. Hughes, Kenneth R. Wright, Harry L. Uy et al. · Journal of Bone and Mineral Research · 1995 · 1K citations

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Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure.

Masahiko Sato, W A Grasser, Naoto Endo et al. · Journal of Clinical Investigation · 1991 · 1K citations · Full text

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Cellular and molecular mechanisms of action of bisphosphonates

Michael J. Rogers, Sharon Gordon, Helena L. Benford et al. · Cancer · 2000 · 712 citations · Full text

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Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation <i>in vitro</i>

John Fisher, Michael J. Rogers, J. M. Halasy et al. · Proceedings of the National Academy of Sciences · 1999 · 679 citations

Medicine, Biochemistry, Pharmacology +17