Concepedia

Scaffold Proteins

Scaffold Proteins is a type of non-enzymatic, multi-domain regulatory protein that functions as a molecular platform to tether multiple signaling and junctional components into spatially and temporally organized complexes, thereby controlling the specificity, efficiency, and integration of cell signaling pathways.

3.2K

Publications

219.4K

Citations

16.9K

Authors

2.6K

Institutions

Publications per year

2017–2026

758

Variants

Scaffolding Proteins

Parents

Children

Publications

3.2K

Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders

Christelle M. Durand, Catalina Betancur, Tobias M. Boeckers et al. · Nature Genetics · 2006 · 1.6K citations · Full text

, , +12

Synthetic protein scaffolds provide modular control over metabolic flux

John E. Dueber, Gabriel C. Wu, G. Reza Malmirchegini et al. · Nature Biotechnology · 2009 · 1.2K citations

, , +16

Wnt Induces LRP6 Signalosomes and Promotes Dishevelled-Dependent LRP6 Phosphorylation

Josipa Bilić, Ya‐Lin Huang, Gary Davidson et al. · Science · 2007 · 934 citations

, , +16

Identification of Peptide and Protein Ligands for the Caveolin-scaffolding Domain

Jacques Couët, Shengwen Calvin Li, Takashi Okamoto et al. · Journal of Biological Chemistry · 1997 · 919 citations · Full text

, , +17

β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3

Patricia McDonald, Chi-wing Chow, William E. Miller et al. · Science · 2000 · 813 citations

, , +17

1–5 of 3.2K

Authors

16.9K

  1. EA
    Edward A. Bayer

    Weizmann Institute of Science, Israel

    47 publications · 2.7K citations

    29

    h-index

  2. RL
    Raphael Lamed

    Tel Aviv University, Israel

    31 publications · 2.2K citations

    24

    h-index

  3. PE
    Peter E. Prevelige

    University of Alabama at Birmingham, United States

    19 publications · 1.4K citations

    18

    h-index

  4. BA
    Bentley A. Fane

    University of Arizona, United States

    18 publications · 662 citations

    17

    h-index

  5. MZ
    Mingjie Zhang

    Hong Kong University of Science and Technology, Hong Kong SAR China

    17 publications · 914 citations

    16

    h-index

1–5 of 16.9K

Institutions

2.6K

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    71 h-index

    322 publications

    55.7K citations

  2. Harvard University

    Cambridge, United States

    63 h-index

    351 publications

    46K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    50 h-index

    547 publications

    32.5K citations

  4. Inserm

    Paris, France

    43 h-index

    402 publications

    26K citations

  5. National Institutes of Health

    Bethesda, United States

    41 h-index

    255 publications

    18.9K citations

  6. University of California, San Francisco

    San Francisco, United States

    38 h-index

    201 publications

    27.3K citations

  7. Massachusetts Institute of Technology

    Cambridge, United States

    35 h-index

    103 publications

    14.7K citations

  8. Yale University

    New Haven, United States

    35 h-index

    183 publications

    22.3K citations

1–8 of 2.6K

Venues

  1. Journal of Biological Chemistry

    JBC · 360 publications · 26.5K citations

    90

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 140 publications · 16.3K citations

    80

    h-index

  3. The Journal of Cell Biology

    JCB · 75 publications · 10.2K citations

    54

    h-index

  4. Molecular and Cellular Biology

    MCB · 78 publications · 7.2K citations

    50

    h-index

  5. Nature Communications

    77 publications · 6K citations

    46

    h-index

1–5