Concepedia

Structure-guided Scaffold Optimization

Structure-Guided Scaffold Optimization is a computational or experimental methodology in protein scaffold engineering that uses high-resolution structural information of protein scaffolds as the primary criterion to iteratively refine and enhance their stability, functionality, or binding specificity.

25

Publications

1.3K

Citations

213

Authors

62

Institutions

Publications per year

2017–2026

10

Parents

Publications

25

Design and synthesis of conformationally constrained amino acids as versatile scaffolds and peptide mimetics

Stephen Hanessian, Grant McNaughton‐Smith, Henry‐Georges Lombart et al. · Tetrahedron · 1997 · 630 citations

, , +16

Design of an Optimized Scaffold for Affibody Molecules

Joachim Feldwisch, Vladimir Tolmachev, Christofer Lendel et al. · Journal of Molecular Biology · 2010 · 184 citations

, , +14

A 45-Amino-Acid Scaffold Mined from the PDB for High-Affinity Ligand Engineering

Max A. Kruziki, Sumit Bhatnagar, Daniel Woldring et al. · Chemistry & Biology · 2015 · 55 citations · Full text

, , +14

Novel scaffold for cathepsin K inhibitors

Naoki Teno, Takahiro Miyake, Takeru Ehara et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 41 citations · Full text

, , +14

Structure-based design and optimization of potent renin inhibitors on 5- or 7-azaindole-scaffolds

Hans Matter, Bodo Scheiper, Henning Steinhagen et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 29 citations · Full text

, , +13

1–5 of 25

Authors

213

  1. JA
    Julie A. Krueger

    United States Military Academy, United States

    2 publications · 24 citations

    2

    h-index

  2. KJ
    Kellie J. Cutrona

    United States Military Academy, United States

    2 publications · 24 citations

    2

    h-index

  3. CP
    Christophe Pannecouque

    Rega Institute for Medical Research, Belgium

    2 publications · 49 citations

    2

    h-index

  4. BJ
    Bobby J. Lucas

    United States Military Academy, United States

    2 publications · 24 citations

    2

    h-index

  5. MG
    Mark G. Solinsky

    Procter & Gamble (United States), United States

    2 publications · 24 citations

    2

    h-index

1–5 of 213

Institutions

62

  1. Guangdong Pharmaceutical University

    Guangzhou, China

    2 h-index

    6 publications

    109 citations

  2. United States Military Academy

    West Point, United States

    2 h-index

    21 publications

    247 citations

  3. KU Leuven

    Leuven, Belgium

    2 h-index

    5 publications

    121 citations

  4. Shandong University

    Jinan, China

    2 h-index

    15 publications

    363 citations

  5. Rega Institute for Medical Research

    Leuven, Belgium

    2 h-index

    5 publications

    121 citations

  6. University of Ljubljana

    Ljubljana, Slovenia

    2 h-index

    7 publications

    84 citations

  7. Universitat de Barcelona

    Barcelona, Spain

    1 h-index

    3 publications

    42 citations

  8. University of Zurich

    Zurich, Switzerland

    1 h-index

    2 publications

    54 citations

1–8 of 62

Venues

  1. Bioorganic & Medicinal Chemistry Letters

    7 publications · 134 citations

    7

    h-index

  2. European Journal of Medicinal Chemistry

    4 publications · 80 citations

    4

    h-index

  3. Bioorganic Chemistry

    3 publications · 44 citations

    3

    h-index

  4. Journal of Medicinal Chemistry

    2 publications · 39 citations

    2

    h-index

  5. Bioorganic & Medicinal Chemistry

    1 publications · 12 citations

    1

    h-index

1–5