Bobby J. Lucas

Metabolism-Directed Optimization of 3-Aminopyrazinone Acetamide Thrombin Inhibitors. Development of an Orally Bioavailable Series Containing P1 and P3 Pyridines

Christopher S. Burgey, Kyle A. Robinson, Terry A. Lyle et al. · Journal of Medicinal Chemistry · 2003 · 121 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +17

Design and Synthesis of a Series of Potent and Orally Bioavailable Noncovalent Thrombin Inhibitors That Utilize Nonbasic Groups in the P1 Position

Thomas J. Tucker, Stephen F. Brady, William C. Lumma et al. · Journal of Medicinal Chemistry · 1998 · 105 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery and Evaluation of Potent P₁ Aryl Heterocycle-Based Thrombin Inhibitors

Mary Beth Young, James C. Barrow, Kristen L. Glass et al. · Journal of Medicinal Chemistry · 2004 · 93 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Design of Novel, Potent, Noncovalent Inhibitors of Thrombin with Nonbasic P-1 Substructures:  Rapid Structure−Activity Studies by Solid-Phase Synthesis

William C. Lumma, Keith M. Witherup, Thomas J. Tucker et al. · Journal of Medicinal Chemistry · 1998 · 86 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Efficacious, Orally Bioavailable Thrombin Inhibitors Based on 3-Aminopyridinone or 3-Aminopyrazinone Acetamide Peptidomimetic Templates

Philip E.J. Sanderson, Terry A. Lyle, Kellie J. Cutrona et al. · Journal of Medicinal Chemistry · 1998 · 85 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14