Discovery and Evaluation of Potent P₁ Aryl Heterocycle-Based Thrombin Inhibitors

Mary Beth Young, James C. Barrow, Kristen L. Glass, +23

Journal of Medicinal Chemistry

Molecular DockingCombinatorial ChemistryMedicinal ChemistryThrombin KDrug Target +13

Discovery of Oxadiazoyl Tertiary Carbinamine Inhibitors of β-Secretase (BACE-1)

Hemaka A. Rajapakse, Philippe G. Nantermet, Harold G. Selnick, +18

Journal of Medicinal Chemistry

The discovery of fused pyrrole carboxylic acids as novel, potent d-amino acid oxidase (DAO) inhibitors

Tim Sparey, Pravien Abeywickrema, Sarah Almond, +14

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryBiochemistryMedicineNatural Sciences +5

The Behavioral and Neurochemical Effects of a Novel d-Amino Acid Oxidase Inhibitor Compound 8 [4 H-Thieno [3,2-b]pyrrole-5-carboxylic Acid] and d-Serine

Sean M. Smith, Jason M. Uslaner, Lihang Yao, +15

Journal of Pharmacology and Experimental Therapeutics

A mild and efficient one pot synthesis of 1,3,4-oxadiazoles from carboxylic acids and acyl hydrazides

Hemaka A. Rajapakse, Hong Zhu, Mary Beth Young, +1

Tetrahedron Letters

Chemical EngineeringEfficient OneCarboxylic AcidsEngineeringNatural Sciences +6

A radiographic comparison of the male and female pelvis.

Mary Beth Young, J G Ince

PubMed

Urogenital RadiologyRadiographic ComparisonMusculoskeletal ImagingPelvic ProlapsePelvic Floor Dysfunction +3

Abnormal localisation and hyperclustering of αVβ3 integrins and associated proteins in Src-deficient or tyrphostin A9-treated osteoclasts

Päivi T. Lakkakorpi, I. Nakamura, Mary Beth Young, +3

Journal of Cell Science

αVβ3 IntegrinsSclerostinAssociated ProteinsMolecular BiologyCytoskeleton +18

Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors

Stacey R. Lindsley, Keith P. Moore, Hemaka A. Rajapakse, +20

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryMedicineDrug DiscoveryAnti-cancer Agent +4

Substituted tetrahydroquinolines as potent allosteric inhibitors of reverse transcriptase and its key mutants

Dai‐Shi Su, John J. Lim, Elizabeth Tinney, +23

Bioorganic & Medicinal Chemistry Letters

BiochemistryMedicineDrug DiscoveryReverse TranscriptasePotent Allosteric Inhibitors +5

Biaryl Ethers as Novel Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Key Mutant Viruses

Dai‐Shi Su, John J. Lim, Elizabeth Tinney, +20

Journal of Medicinal Chemistry

Viral ReplicationMolecular BiologyKey Mutant VirusesPharmacotherapyAntiviral Drug +17