Detecting S-adenosyl-l-methionine-induced conformational change of a histone methyltransferase using a homogeneous time-resolved fluorescence-based binding assay

Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor

Scott R. Daigle, Edward J. Olhava, Carly A. Therkelsen et al. · Cancer Cell · 2011 · 923 citations · Full text

Hematological Malignancy, Tumor Biology, Selective Killing +8

Reversal of H3K9me2 by a Small-Molecule Inhibitor for the G9a Histone Methyltransferase

Stefan Kubicek, Roderick J. O’Sullivan, Elias August et al. · Molecular Cell · 2007 · 841 citations

Histone Modifications, Chromatin, Chromatin Remodeling +12

Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9

Dorothea Greiner, Tiziana Bonaldi, Ragnhild Eskeland et al. · Nature Chemical Biology · 2005 · 518 citations · Full text

Histone Modifications, Chromatin, Histone Methyltransferase Su +9

Structure and catalytic mechanism of the human histone methyltransferase SET7/9

Bing Xiao, Chun Jing, J. Wilson et al. · Nature · 2003 · 376 citations

Histone Modifications, Chromatin, Chromatin Structure +14

Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294

Yanqi Chang, Xing Zhang, J.R. Horton et al. · Nature Structural & Molecular Biology · 2009 · 305 citations · Full text

Protein Chemistry, Biochemistry, Protein Assembly +9