Chromatin Structure

Chromatin Structure is the hierarchical organization of eukaryotic genomic DNA and histone proteins into nucleosomes and condensed higher-order complexes that regulates the accessibility of genetic information.

36.6K

Publications

3.2M

Citations

97.3K

Authors

7.7K

Institutions

Publications per year

2017–2026

6.6K

Parents

Molecular BiologyMolecular Genetics

Children

ChromatinChromosome Territory OrganizationHistone ModificationsHistone ProteinsHistone VariantsLinker DnaNucleosome OrganizationNucleosome PositioningTopologically Associating Domains

Publications

36.6K

A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping

Suhas S.P. Rao, Miriam Huntley, Neva C. Durand et al. · Cell · 2014 · 9.9K citations · Full text

Life Sciences, Genetics, Molecular Genetics +14

Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

Erez Lieberman-Aiden, Nynke L. van Berkum, Louise Williams et al. · Science · 2009 · 9.6K citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Crystal structure of the nucleosome core particle at 2.8 Å resolution

Karolin Luger, Armin W. Mäder, Robin K. Richmond et al. · Nature · 1997 · 9.4K citations

Life Sciences, Biophysics, Molecular Biology +14

The language of covalent histone modifications

Brian D. Strahl, C. David Allis · Nature · 2000 · 8.6K citations

Life Sciences, Biochemistry, Molecular Biology +12

Topological domains in mammalian genomes identified by analysis of chromatin interactions

Jesse R. Dixon, Siddarth Selvaraj, Feng Yue et al. · Nature · 2012 · 7.4K citations · Full text

Life Sciences, Genetics, Molecular Biology +16

1–5 of 36.6K

Authors

97.3K

CD
C. David Allis
Rockefeller University, United States
164 publications · 57K citations
103
h-index
SH
Steven Henikoff
Fred Hutch Cancer Center, United States
108 publications · 21.2K citations
72
h-index
WC
William C. Earnshaw
University of Edinburgh, United Kingdom
106 publications · 16K citations
65
h-index
GA
Geneviève Almouzni
Institut Curie, France
90 publications · 12.9K citations
61
h-index
KL
Karolin Luger
Colorado State University, United States
98 publications · 23.9K citations
61
h-index

1–5 of 97.3K

Institutions

7.7K

1–8 of 7.7K

Venues

Cell
686 publications · 249.2K citations
293
h-index
Nature
665 publications · 237.7K citations
248
h-index
Molecular Cell
663 publications · 125.2K citations
208
h-index
Proceedings of the National Academy of Sciences
PNAS · 1.4K publications · 178.5K citations
208
h-index
The Journal of Cell Biology
JCB · 850 publications · 120.5K citations
196
h-index

1–5

See also Chromatin Structure
Core Components	Histone Variants Linker Dna Insulator Proteins Atp-dependent Chromatin Remodeling
Organization Levels	Chromatin Chromatin Loops Chromosome Territories Heterochromatin Organization Higher-order Chromatin Architecture Topologically Associating Domains A/b Chromatin Compartments
Regulatory Mechanisms	Histone Modifications Dna Methylation Histone Acetylation Histone Methylation Histone Variants Histone Deacetylases Nucleosome Positioning Histone Demethylases Histone Acetyltransferases Atp-dependent Chromatin Remodeling Histone Methyltransferases Non-coding Rna Regulation
Functional Roles	Chromatin Transcriptional Regulation Dna Replication Chromatin Loops Dna Packaging Stem Cell Differentiation Gene Expression Regulation Dna Repair Recombination Topologically Associating Domains A/b Chromatin Compartments
Analytical Methods	Chromosome Conformation Capture Hierarchical Clustering Graph Embeddings K-means Clustering Gaussian Hidden Markov Models Hi-c Micro-c Circular Chromosome Conformation Capture Single-cell Hi-c