Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation

Hideharu Hashimoto, Yiwei Liu, Anup K. Upadhyay, +5

Nucleic Acids Research

Potential MechanismsEpigenetic ChangeGeneticsDna MethylationGenomic Mechanism +19

Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294

Yanqi Chang, Xing Zhang, J.R. Horton, +6

Nature Structural & Molecular Biology

Protein ChemistryBiochemistryProtein AssemblyProtein FoldingNatural Sciences +7

Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling

Dan Levy, Alex Kuo, Yanqi Chang, +21

Nature Immunology

Histone ModificationsTonic RepressionMolecular RegulationEpigenetic ChangeGenetics +16

A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability

Pierre‐Olivier Estève, Yanqi Chang, Mala Samaranayake, +5

Nature Structural & Molecular Biology

ChromatinSignal TransductionMedicineGeneticsNatural Sciences +8

MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a

Yanqi Chang, Lidong Sun, Kenji Kokura, +10

Nature Communications

ChromatinH3k9 Methyltransferase Glp/g9aGeneticsDna MethylationNatural Sciences +11

Adding a Lysine Mimic in the Design of Potent Inhibitors of Histone Lysine Methyltransferases

Yanqi Chang, Thota Ganesh, J.R. Horton, +8

Journal of Molecular Biology

Histone ModificationsMedicinal ChemistryBiochemistryHistone Lysine MethyltransferasesLysine Mimic +10

Structural basis for a pH-sensitive calcium leak across membranes

Yanqi Chang, Renato Bruni, Brian Kloss, +5

Science

Molecular BiologyPh-sensitive Calcium LeakCellular PhysiologyMembrane TransportProtein X-ray Crystallography +15

Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling

Yanqi Chang, Dan Levy, J.R. Horton, +4

Nucleic Acids Research

An Analog of BIX-01294 Selectively Inhibits a Family of Histone H3 Lysine 9 Jumonji Demethylases

Anup K. Upadhyay, Dante Rotili, Ji Woong Han, +7

Journal of Molecular Biology

Histone ModificationsChromatinBix-01294 SelectivelyJumonji DemethylasesNatural Sciences +9

Structural Insights for MPP8 Chromodomain Interaction with Histone H3 Lysine 9: Potential Effect of Phosphorylation on Methyl-Lysine Binding

Yanqi Chang, J.R. Horton, Mark T. Bedford, +2

Journal of Molecular Biology

Histone ModificationsChromatinSignal TransductionChromatin StructureBiochemistry +10