The contribution of de novo coding mutations to autism spectrum disorder

Ivan Iossifov, Brian J. O’Roak, Stephan Sanders, +44

Nature

Neurodevelopmental DisordersSpectrum DisorderSyndromic AutismGenetic DisorderGenetics +6

Tumour evolution inferred by single-cell sequencing

Nicholas E. Navin, Jude Kendall, Jennifer Troge, +12

Nature

Tumor BiologyTumor HeterogeneityMedicineSingle Cell SequencingSingle-cell Genomics +6

De Novo Gene Disruptions in Children on the Autistic Spectrum

Ivan Iossifov, Michael Ronemus, Dan Levy, +32

Neuron

Developmental BiologySyndromic AutismGenetic DisorderGeneticsAutism +6

Rare De Novo and Transmitted Copy-Number Variation in Autistic Spectrum Disorders

Dan Levy, Michael Ronemus, Boris Yamrom, +14

Neuron

Neurodevelopmental DisordersRare De NovoPsychiatrySyndromic AutismGenetic Disorder +8

Rare De Novo Variants Associated with Autism Implicate a Large Functional Network of Genes Involved in Formation and Function of Synapses

Sarah R Gilman, Ivan Iossifov, Dan Levy, +3

Neuron

Neurodevelopmental DisordersSynaptic PlasticityMolecular NeuroscienceSyndromic AutismGenetic Disorder +13

Inferring tumor progression from genomic heterogeneity

Nicholas E. Navin, Alexander Krasnitz, Linda Rodgers, +13

Genome Research

EngineeringGeneticsPathologyGenomicsTumor Biology +18

Yap1 Phosphorylation by c-Abl Is a Critical Step in Selective Activation of Proapoptotic Genes in Response to DNA Damage

Dan Levy, Yaarit Adamovich, Nina Reuven, +1

Molecular Cell

Protein FunctionSignal TransductionDna DamageMedicineApoptosis +7

The maize methylome influences mRNA splice sites and reveals widespread paramutation-like switches guided by small RNA

Michael Regulski, Zhenyuan Lu, Jude Kendall, +12

Genome Research

Epigenetic ChangeGeneticsRna SplicingMolecular BiologyMolecular Genetics +20

Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling

Dan Levy, Alex Kuo, Yanqi Chang, +21

Nature Immunology

Histone ModificationsTonic RepressionMolecular RegulationEpigenetic ChangeGenetics +16

The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73

Dan Levy, Yaarit Adamovich, Nina Reuven, +1

Cell Death and Differentiation

Protein FunctionSignal TransductionSignaling PathwayReceptor Tyrosine KinaseYes-associated Protein 1 +6