5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging

Keith E. Szulwach, Xuekun Li, Yujing Li, +13

Nature Neuroscience

ChromatinDevelopmental BiologyBrain DevelopmentMedicineEpigenetic Change +8

Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation

Hideharu Hashimoto, Yiwei Liu, Anup K. Upadhyay, +5

Nucleic Acids Research

Potential MechanismsEpigenetic ChangeGeneticsDna MethylationGenomic Mechanism +19

Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases

J.R. Horton, Anup K. Upadhyay, Hank H. Qi, +3

Nature Structural & Molecular Biology

ChromatinBiochemistryNatural SciencesSubstrate SpecificityEpigenomics +7

Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294

Yanqi Chang, Xing Zhang, J.R. Horton, +6

Nature Structural & Molecular Biology

Protein ChemistryBiochemistryProtein AssemblyProtein FoldingNatural Sciences +7

A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability

Pierre‐Olivier Estève, Yanqi Chang, Mala Samaranayake, +5

Nature Structural & Molecular Biology

ChromatinSignal TransductionMedicineGeneticsNatural Sciences +8

The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity

Kenneth D. Bromberg, Taylor R. H. Mitchell, Anup K. Upadhyay, +28

Nature Chemical Biology

ChromatinChromatin RemodelingEpigenetic ChangeGeneticsGenomic Integrity +8

hNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing

Chung-Fan Lee, Shi‐Chen Ou, Sung‐Bau Lee, +10

Journal of Clinical Investigation

Hnaa10p ContributesCancer BiologyEpigeneticsTumor BiologyTranscriptional Regulation +15

Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor

Jing Zhao, Yuhong Du, J.R. Horton, +12

Proceedings of the National Academy of Sciences

Crystal structure of full-length <i>Zika virus</i> NS5 protein reveals a conformation similar to <i>Japanese encephalitis virus</i> NS5

Anup K. Upadhyay, Matthew G. Cyr, Kenton L. Longenecker, +3

Acta Crystallographica Section F Structural Biology Communications

Locating the critical failure surface in a slope stability analysis by genetic algorithm

Aniruddha Sengupta, Anup K. Upadhyay

Applied Soft Computing

Geotechnical EngineeringReliability EngineeringEngineeringSlope StabilityRock Slope +12