Concepedia

The effect of celastrol, a triterpene with antitumorigenic activity, on conformational and functional aspects of the human 90kDa heat shock protein Hsp90α, a chaperone implicated in the stabilization of the tumor phenotype

L.M. Zanphorlin, Fernanda Rosa Alves, Carlos H.I. Ramos

Biochimica et Biophysica Acta (BBA) - General Subjects · 2014 · 28 citations · 34 references

DOI

Concepts

References

34

The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability

F. Niesen, H. Berglund, Masoud Vedadi · Nature Protocols · 2007 · 2.4K citations

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Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.

Luke Whitesell, Edward G. Mimnaugh, B. de Costa et al. · Proceedings of the National Academy of Sciences · 1994 · 1.4K citations

, , +14

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

Adeela Kamal, Lia Thao, John Sensintaffar et al. · Nature · 2003 · 1.4K citations

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Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin

S. Mark Roe, Chrisostomos Prodromou, Ronan O’Brien et al. · Journal of Medicinal Chemistry · 1999 · 999 citations · Full text

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Thermofluor-based high-throughput stability optimization of proteins for structural studies

U.B. Ericsson, B.M. Hallberg, George T. DeTitta et al. · Analytical Biochemistry · 2006 · 843 citations

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