A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

Hsp90 as a capacitor for morphological evolution

Suzanne L. Rutherford, Susan Lindquist · Nature · 1998 · 2.3K citations

Life Sciences, Biology, Molecular Biology +5

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.

Luke Whitesell, Edward G. Mimnaugh, B. de Costa et al. · Proceedings of the National Academy of Sciences · 1994 · 1.4K citations

Life Sciences, Molecular Biology, Pharmacology +14

Hsp90 as a capacitor of phenotypic variation

Christine Queitsch, Todd A. Sangster, Susan Lindquist · Nature · 2002 · 1.4K citations

Life Sciences, Biology, Molecular Biology +7

Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent

C. Erec Stebbins, Alicia A. Russo, Christine Schneider et al. · Cell · 1997 · 1.4K citations · Full text

Life Sciences, Biochemistry, Oncology +17

Identification and Structural Characterization of the ATP/ADP-Binding Site in the Hsp90 Molecular Chaperone

Chrisostomos Prodromou, S. Mark Roe, Ronan O’Brien et al. · Cell · 1997 · 1.3K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16