Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

Alison Goate, Marie‐Christine Chartier‐Harlin, Jeremy Brown et al. · Nature · 1991 · 4.6K citations

Alzheimer's Disease, Genetics, Missense Mutation +9

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

Robin Sherrington, Yuh‐Jin Liang, Ekaterina Rogaeva et al. · Nature · 1995 · 4K citations

Neurodegenerative Diseases, Early-onset Familial Alzheimer, Alzheimer's Disease +7

Candidate Gene for the Chromosome 1 Familial Alzheimer's Disease Locus

Ephrat Levy‐Lahad, Wilma Wasco, Parvoneh Poorkaj et al. · Science · 1995 · 2.6K citations

Alzheimer's Disease, Genetic Disorder, Genetics +12

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

Donalyn Scheuner, Christopher B. Eckman, M. Jensen et al. · Nature Medicine · 1996 · 2.6K citations

Molecular Biology, Synaptic Signaling, Social Sciences +16

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

Dora Games, David S. Adams, Ree Alessandrini et al. · Nature · 1995 · 2.5K citations

Alzheimer-type Neuropathology, Neurodegenerative Diseases, Alzheimer's Disease +12