Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

Alison Goate, Marie‐Christine Chartier‐Harlin, Jeremy Brown, +17

Nature

Alzheimer's DiseaseGeneticsMissense MutationMolecular BiologyPrion Disease +7

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

Robin Sherrington, Yuh‐Jin Liang, Ekaterina Rogaeva, +28

Nature

Neurodegenerative DiseasesEarly-onset Familial AlzheimerAlzheimer's DiseaseGenetic DisorderGenetics +5

Candidate Gene for the Chromosome 1 Familial Alzheimer's Disease Locus

Ephrat Levy‐Lahad, Wilma Wasco, Parvoneh Poorkaj, +16

Science

Alzheimer's DiseaseGenetic DisorderGeneticsMolecular BiologyPoint Mutation +10

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

Donalyn Scheuner, Christopher B. Eckman, M. Jensen, +18

Nature Medicine

Molecular BiologySynaptic SignalingSocial SciencesPresenilin 1Alzheimer's Disease +14

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

Dora Games, David S. Adams, Ree Alessandrini, +31

Nature

Alzheimer-type NeuropathologyNeurodegenerative DiseasesAlzheimer's DiseaseMolecular NeuroscienceTransgenic Mouse Models +10

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

Robin Sherrington, Ekaterina Rogaeva, Georges Lévesque, +17

Nature

Disease HeterogeneityAlzheimer's DiseaseMendelian DisorderGenetic DisorderGenetics +8

Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo

Gopal Thinakaran, David Borchelt, Michael K. Lee, +14

Neuron

Pharmaceutical ScienceBiochemistryPharmacologyPharmaceutical ChemistryPresenilin 1

Introns increase transcriptional efficiency in transgenic mice.

Ralph L. Brinster, J M Allen, Richard R. Behringer, +2

Proceedings of the National Academy of Sciences

Knockout MouseTranscriptional RegulationMurine Germ LineDevelopmental BiologyProtein Expression +11

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

Diane Levitan, Iva Greenwald

Nature

Systems BiologySignal TransductionMolecular NeuroscienceSignaling PathwayMolecular Pathway +9

Amyloid β Protein (Aβ) in Alzheimeri's Disease Brain

Stephen A. Gravina, Libin Ho, Christopher B. Eckman, +5

Journal of Biological Chemistry