Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP

Jada Lewis, Dennis W. Dickson, Wen-Lang Lin, +11

Science

Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

David Borchelt, Gopal Thinakaran, Christopher B. Eckman, +17

Neuron

Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

Karen Duff, Chris Eckman, Cindy Zehr, +14

Nature

Neurodegenerative DiseasesMolecular NeuroscienceMutant Presenilin 1Degenerative PathologyProtein Misfolding +7

Substrate-targeting γ-secretase modulators

Thomas Kukar, Thomas B. Ladd, Maralyssa Bann, +26

Nature

Protein SecretionSignal TransductionProtein ExpressionBiochemistryNatural Sciences +3

Differential Expression of Cholesterol Hydroxylases in Alzheimer's Disease

James A. Brown, Catherine Theisler, Simone Silberman, +10

Journal of Biological Chemistry

A New Pathogenic Mutation in the APP Gene (I716V) Increases the Relative Proportion of A 42(43)

Chris Eckman, Nitin D. Mehta, Richard Crook, +12

Human Molecular Genetics

Flemish and Dutch Mutations in Amyloid β Precursor Protein Have Different Effects on Amyloid β Secretion

Chris De Jonghe, Cynthia Zehr, Debra Yager, +5

Neurobiology of Disease

Protein FoldingGeneticsMolecular BiologyDutch MutationsPrion Disease +3

Increased Aβ42(43) from cell lines expressing presenilin 1 mutations

Nitin D. Mehta, Lawrence M. Refolo, Chris Eckman, +7

Annals of Neurology

Alzheimer's DiseaseDementiaGeneticsCell LinesDegenerative Pathology +12

Plasma amyloid β protein is elevated in late-onset Alzheimer disease families

Nilüfer Ertekin‐Taner, Linda H. Younkin, Debra Yager, +6

Neurology

Neuronal Expression of β-Amyloid Precursor Protein Alzheimer Mutations Causes Intracellular Accumulation of a C-terminal Fragment Containing Both the Amyloid β and Cytoplasmic Domains

Donna L. McPhie, Robert K. K. Lee, Christopher B. Eckman, +6

Journal of Biological Chemistry

Amyloid βMolecular BiologyNeurochemical BiomarkersSynaptic SignalingSocial Sciences +18