David Borchelt

APP Processing and Synaptic Function

Flavio Kamenetz, Taisuke Tomita, Helen Hsieh et al. · Neuron · 2003 · 1.6K citations · Full text

Life Sciences, Neurobiology, Neuroscience +13

Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase

Joanna L. Jankowsky, Daniel J. Fadale, Jeffrey C. Anderson et al. · Human Molecular Genetics · 2003 · 1.6K citations · Full text

Life Sciences, Neurology, Neuroscience +16

Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

David Borchelt, Gopal Thinakaran, Christopher B. Eckman et al. · Neuron · 1996 · 1.5K citations · Full text

Life Sciences, Molecular Biology, Neuroscience +17

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

Philip C. Wong, Carlos A. Pardo, David Borchelt et al. · Neuron · 1995 · 1.4K citations

Life Sciences, Neurology, Neuroscience +17

ALS-Linked SOD1 Mutant G85R Mediates Damage to Astrocytes and Promotes Rapidly Progressive Disease with SOD1-Containing Inclusions

Lucie Bruijn, Mark W. Bêcher, Michael K. Lee et al. · Neuron · 1997 · 1.3K citations · Full text

Life Sciences, Neurology, Neuroscience +17