Thomas Kukar

TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD

Ching-Chieh Chou, Yi Zhang, Mfon Umoh et al. · Nature Neuroscience · 2018 · 568 citations · Full text

Sporadic Als, Molecular Biology, Neurochemical Biomarkers +17

Diverse compounds mimic Alzheimer disease–causing mutations by augmenting Aβ42 production

Thomas Kukar, M. Paul Murphy, Jason L. Eriksen et al. · Nature Medicine · 2005 · 278 citations

Neurodegenerative Diseases, Alzheimer's Disease, Biochemistry +12

Substrate-targeting γ-secretase modulators

Thomas Kukar, Thomas B. Ladd, Maralyssa Bann et al. · Nature · 2008 · 275 citations · Full text

Protein Secretion, Signal Transduction, Protein Expression +5

FUS is Phosphorylated by DNA-PK and Accumulates in the Cytoplasm after DNA Damage

Qiudong Deng, Christopher J. Holler, Geraldine Taylor et al. · Journal of Neuroscience · 2014 · 160 citations · Full text

Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by<i>GRN</i>Mutations

Christopher J. Holler, Georgia Taylor, Qiudong Deng et al. · eNeuro · 2017 · 132 citations · Full text