Xin Yu

Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

Karen Duff, Chris Eckman, Cindy Zehr et al. · Nature · 1996 · 1.4K citations

Neurodegenerative Diseases, Molecular Neuroscience, Mutant Presenilin 1 +9

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

Leigh A. Holcomb, Marcia N. Gordon, Eileen McGowan et al. · Nature Medicine · 1998 · 1.4K citations

Neurodegenerative Diseases, Molecular Neuroscience, Alzheimer's Disease +12

Wild-Type Human TDP-43 Expression Causes TDP-43 Phosphorylation, Mitochondrial Aggregation, Motor Deficits, and Early Mortality in Transgenic Mice

Ya-Fei Xu, Tania F. Gendron, Yong‐Jie Zhang et al. · Journal of Neuroscience · 2010 · 560 citations · Full text

A Loss of Function Mutation of Presenilin-2 Interferes with Amyloid β-Peptide Production and Notch Signaling

Harald Steiner, Karen Duff, Anja Capell et al. · Journal of Biological Chemistry · 1999 · 307 citations · Full text

Characterization of Pathology in Transgenic Mice Over-Expressing Human Genomic and cDNA Tau Transgenes

Karen Duff, Heather Knight, Lorenzo M. Refolo et al. · Neurobiology of Disease · 2000 · 301 citations · Full text

Knockout Mouse, Transgenic Mouse Models, Genetics +7