Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

Karen Duff, Chris Eckman, Cindy Zehr, +14

Nature

Neurodegenerative DiseasesMolecular NeuroscienceMutant Presenilin 1Degenerative PathologyProtein Misfolding +7

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

Leigh A. Holcomb, Marcia N. Gordon, Eileen McGowan, +16

Nature Medicine

Neurodegenerative DiseasesMolecular NeuroscienceAlzheimer's DiseaseTransgenic Mouse ModelsDegenerative Pathology +10

Wild-Type Human TDP-43 Expression Causes TDP-43 Phosphorylation, Mitochondrial Aggregation, Motor Deficits, and Early Mortality in Transgenic Mice

Ya-Fei Xu, Tania F. Gendron, Yong‐Jie Zhang, +13

Journal of Neuroscience

A Loss of Function Mutation of Presenilin-2 Interferes with Amyloid β-Peptide Production and Notch Signaling

Harald Steiner, Karen Duff, Anja Capell, +16

Journal of Biological Chemistry

Characterization of Pathology in Transgenic Mice Over-Expressing Human Genomic and cDNA Tau Transgenes

Karen Duff, Heather Knight, Lorenzo M. Refolo, +9

Neurobiology of Disease

Knockout MouseTransgenic Mouse ModelsGeneticsGenetic EngineeringCdna Tau Transgenes +5

Accelerated Lipofuscinosis and Ubiquitination in Granulin Knockout Mice Suggest a Role for Progranulin in Successful Aging

Zeshan Ahmed, Sheng Hong, Ya-Fei Xu, +14

American Journal Of Pathology

InflammationLifespan ExtensionSuccessful AgingAutophagyCell Death +6

Lack of Nigral Pathology in Transgenic Mice Expressing Human α-Synuclein Driven by the Tyrosine Hydroxylase Promoter

Yasuji Matsuoka, Miquel Vila, Sarah Lincoln, +12

Neurobiology of Disease

Knockout MouseNeurodegenerative DiseasesMedicineGeneticsTyrosine Hydroxylase Promoter +3

Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

Heather L. Melrose, Justus C. Dächsel, Bahareh Behrouz, +23

Neurobiology of Disease

Knockout MouseNeurodegenerative DiseasesSignal TransductionMolecular NeuroscienceMolecular Physiology +8

Cytokines Regulate Gelatinase A and B (Matrix Metalloproteinase 2 and 9) Activity in Cultured Rat Astrocytes

Paul E. Gottschall, Xin Yu

Journal of Neurochemistry

Amyloid Phenotype Characterization of Transgenic Mice Overexpressing both Mutant Amyloid Precursor Protein and Mutant Presenilin 1 Transgenes

Eileen McGowan, Sunny Sanders, Takeshi Iwatsubo, +9

Neurobiology of Disease

Knockout MouseNeurodegenerative DiseasesAlzheimer's DiseaseTransgenic Mouse ModelsAmyloid Phenotype Characterization +7