Structural determinants of the cellular localization and shuttling of TDP-43

Youhna M. Ayala, Paola Zago, Andrea D’Ambrogio, +4

Journal of Cell Science

Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity

Yong‐Jie Zhang, Ya-Fei Xu, Casey Cook, +14

Proceedings of the National Academy of Sciences

ApoptosisCell DeathMolecular BiologyToxicological MechanismAberrant Cleavage +16

ER–mitochondria associations are regulated by the VAPB–PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43

Radu Stoica, Kurt J. De Vos, Sébastien Paillusson, +12

Nature Communications

Wild-Type Human TDP-43 Expression Causes TDP-43 Phosphorylation, Mitochondrial Aggregation, Motor Deficits, and Early Mortality in Transgenic Mice

Ya-Fei Xu, Tania F. Gendron, Yong‐Jie Zhang, +13

Journal of Neuroscience

Progranulin Mediates Caspase-Dependent Cleavage of TAR DNA Binding Protein-43

Yong‐Jie Zhang, Ya-Fei Xu, Chad A. Dickey, +6

Journal of Neuroscience

Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress

Yong‐Jie Zhang, Karen Jansen‐West, Ya-Fei Xu, +18

Acta Neuropathologica

GeneticsAggregation-prone C9ftd/als PolyMolecular BiologyEr StressDegenerative Pathology +15

C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins

Yong‐Jie Zhang, Tania F. Gendron, Jonathan C. Grima, +32

Nature Neuroscience

Protein FunctionSignal TransductionNucleocytoplasmic Transport ProteinsMedicineNatural Sciences +9

Accelerated Lipofuscinosis and Ubiquitination in Granulin Knockout Mice Suggest a Role for Progranulin in Successful Aging

Zeshan Ahmed, Sheng Hong, Ya-Fei Xu, +14

American Journal Of Pathology

InflammationLifespan ExtensionSuccessful AgingAutophagyCell Death +6

Akt and CHIP coregulate tau degradation through coordinated interactions

Chad A. Dickey, John Koren, Yong‐Jie Zhang, +13

Proceedings of the National Academy of Sciences

Protein FunctionAlzheimer's DiseaseSignal TransductionTau ClearanceProtein Folding +12

An Epidemiological and Molecular Study of the Relationship Between Smoking, Risk of Nasopharyngeal Carcinoma, and Epstein–Barr Virus Activation

Feng-Hua Xu, Dan Xiong, Ya-Fei Xu, +16

JNCI Journal of the National Cancer Institute