Neuronal activity enhances tau propagation and tau pathology in vivo

Jessica Wu, S. Abid Hussaini, Isle Bastille, +15

Nature Neuroscience

Neurodegenerative DiseasesAlzheimer's DiseaseTau PathologyExperimental NeuropathologyDegenerative Disease +7

Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity

Yong‐Jie Zhang, Ya-Fei Xu, Casey Cook, +14

Proceedings of the National Academy of Sciences

ApoptosisCell DeathMolecular BiologyToxicological MechanismAberrant Cleavage +16

TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A

X. Rosa, Mercedes Prudencio, Yuka Koike, +31

Nature

An autoradiographic evaluation of AV-1451 Tau PET in dementia

Val J. Lowe, Geoffry L. Curran, Ping Fang, +16

Acta Neuropathologica Communications

Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer’s Disease

Bahareh Eftekharzadeh, J. Gavin Daigle, Larisa E. Kapinos, +27

Neuron

Neurodegenerative DiseasesAlzheimer's DiseaseMolecular NeuroscienceMedicineMolecular Biology +6

Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains

Tamta Arakhamia, Christina E. Lee, Yari Carlomagno, +13

Cell

Tauopathy StrainsStructural BiologyMolecular BiologyDegenerative Disease

Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity

Tara Vanderweyde, Daniel J. Apicco, Katherine Youmans-Kidder, +13

Cell Reports

Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis

Yong‐Jie Zhang, Tania F. Gendron, Mark Ebbert, +20

Nature Medicine

Amyotrophic Lateral SclerosisAlzheimer's DiseaseDementiaProtein TranslationStress Granule Dynamics +7

Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau

Silvia S. Kang, Mark Ebbert, Kelsey E. Baker, +6

The Journal of Experimental Medicine

AgingImmunologyMicroglial PathwaysNeurochemical BiomarkersNeuroinflammation +15

Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance

Casey Cook, Yari Carlomagno, Tania F. Gendron, +8

Human Molecular Genetics