Mercedes Prudencio

TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A

X. Rosa, Mercedes Prudencio, Yuka Koike et al. · Nature · 2022 · 520 citations · Full text

<i>C9ORF72</i> repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits

Jeannie Chew, Tania F. Gendron, Mercedes Prudencio et al. · Science · 2015 · 396 citations · Full text

Mouse Brains, Synaptic Signaling, Social Sciences +17

Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress

Yong‐Jie Zhang, Karen Jansen‐West, Ya-Fei Xu et al. · Acta Neuropathologica · 2014 · 336 citations · Full text

Genetics, Aggregation-prone C9ftd/als Poly, Molecular Biology +17

Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis

Yong‐Jie Zhang, Tania F. Gendron, Mark Ebbert et al. · Nature Medicine · 2018 · 325 citations · Full text

Amyotrophic Lateral Sclerosis, Alzheimer's Disease, Dementia +9

Reduced C9orf72 gene expression in c9FTD/ALS is caused by histone trimethylation, an epigenetic event detectable in blood

Véronique Belzil, Peter Bauer, Mercedes Prudencio et al. · Acta Neuropathologica · 2013 · 311 citations · Full text

Histone Modifications, Epigenetic Change, Genetics +18