Leigh A. Holcomb

Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

Karen Duff, Chris Eckman, Cindy Zehr et al. · Nature · 1996 · 1.4K citations

Neurodegenerative Diseases, Molecular Neuroscience, Mutant Presenilin 1 +9

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

Leigh A. Holcomb, Marcia N. Gordon, Eileen McGowan et al. · Nature Medicine · 1998 · 1.4K citations

Neurodegenerative Diseases, Molecular Neuroscience, Alzheimer's Disease +12

Behavioral Changes in Transgenic Mice Expressing Both Amyloid Precursor Protein and Presenilin-1 Mutations: Lack of Association with Amyloid Deposits

Leigh A. Holcomb, Marcia N. Gordon, Paul Jantzen et al. · Behavior Genetics · 1999 · 349 citations

Time Course of the Development of Alzheimer-like Pathology in the Doubly Transgenic PS1+APP Mouse

Marcia N. Gordon, Leigh A. Holcomb, Paul Jantzen et al. · Experimental Neurology · 2002 · 247 citations

Knockout Mouse, Alzheimer's Disease, Developmental Biology +10

Bile acid feeding induces cholangiocyte proliferation and secretion: Evidence for bile acid–regulated ductal secretion

Gianfranco Alpini, Shannon Glaser, Yoshiyuki Ueno et al. · Gastroenterology · 1999 · 198 citations

Nutrition, Hepatology, Biliary Tract +14