Behavioral Changes in Transgenic Mice Expressing Both Amyloid Precursor Protein and Presenilin-1 Mutations: Lack of Association with Amyloid Deposits

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

Karen Hsiao, Paul F. Chapman, Steven P. Nilsen et al. · Science · 1996 · 4.2K citations

Life Sciences, Neurobiology, Neuroscience +17

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

Donalyn Scheuner, Christopher B. Eckman, M. Jensen et al. · Nature Medicine · 1996 · 2.6K citations

Life Sciences, Neurobiology, Neuroscience +16

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

Dora Games, David S. Adams, Ree Alessandrini et al. · Nature · 1995 · 2.5K citations

Life Sciences, Neurology, Neuroscience +16

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

Martin Citron, Tilman Oltersdorf, Christian Haass et al. · Nature · 1992 · 1.7K citations

Life Sciences, Molecular Biology, Neurology +16

Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

Karen Duff, Chris Eckman, Cindy Zehr et al. · Nature · 1996 · 1.5K citations

Life Sciences, Neurobiology, Neuroscience +12