Concepedia

Synthesis and optimization of novel 4,4-disubstituted cyclohexylbenzamide derivatives as potent 11β-HSD1 inhibitors

Daqing Sun, Zhulun Wang, Seb Caille, Michael DeGraffenreid, Felix González-López de Turiso, Randall W. Hungate, Juan C. Jaén, Ben Jiang, Lisa D. Julian, Ron C. Kelly,

Bioorganic & Medicinal Chemistry Letters · 2010 · 20 citations · 29 references

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29

Novel Adipose Tissue–Mediated Resistance to Diet-Induced Visceral Obesity in 11β-Hydroxysteroid Dehydrogenase Type 1–Deficient Mice

Nicholas M. Morton, Janice M. Paterson, Hiroaki Masuzaki et al. · Diabetes · 2004 · 504 citations · Full text

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11β-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice

Anne Hermanowski‐Vosatka, James M. Balkovec, Kang Cheng et al. · The Journal of Experimental Medicine · 2005 · 363 citations · Full text

, , +17

Arylsulfonamidothiazoles as a New Class of Potential Antidiabetic Drugs. Discovery of Potent and Selective Inhibitors of the 11β-Hydroxysteroid Dehydrogenase Type 1

Tjeerd Barf, Jerk Vallgårda, Rikard Emond et al. · Journal of Medicinal Chemistry · 2002 · 211 citations · Full text

, , +16

Adamantyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1

Steven H. Olson, Susan D. Aster, Kai Brown et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 96 citations

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Synthesis and biological evaluation of sulfonamidooxazoles and β-keto sulfones: selective inhibitors of 11β-hydroxysteroid dehydrogenase type I

Jason Xiang, Manus Ipek, Vipin Suri et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 86 citations · Full text

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